{"id":36025,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/fijacion-a-las-proteinas-plasmaticas-de-morfina-y-metadona-y-su-importancia-en-la-farmacocinetica-y-farmacodinamia\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"fijacion-a-las-proteinas-plasmaticas-de-morfina-y-metadona-y-su-importancia-en-la-farmacocinetica-y-farmacodinamia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/fijacion-a-las-proteinas-plasmaticas-de-morfina-y-metadona-y-su-importancia-en-la-farmacocinetica-y-farmacodinamia\/","title":{"rendered":"Fijacion a las proteinas plasmaticas de morfina y metadona y su importancia en la farmacocinetica y farmacodinamia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Gomez Iglesias <\/strong><\/h2>\n<p>El acceso de f\u00e1rmacos al snc est\u00e1 restringido por la existencia de la barrera hematoencef\u00e1lica. Adem\u00e1s, la fijaci\u00f3n de los f\u00e1rmacos a las prote\u00ednas plasm\u00e1ticas puede favorecer dicha limitaci\u00f3n. Dentro de las prote\u00ednas plasm\u00e1ticas implicadas en la fijaci\u00f3n de f\u00e1rmacos juega un papel importante la alfa-1-glicoprote\u00edna \u00e1cida (aga), en concreto para la fijaci\u00f3n de f\u00e1rmacos de caracter\u00edsticas b\u00e1sicas. Los opioides son un grupo farmacol\u00f3gico con efecto a nivel del snc y con caracter\u00edsticas b\u00e1sicas.  el estudio se realiz\u00f3 con los opioides morfina y metadona, los cuales presentan caracter\u00edsticas farmacocin\u00e9ticas diferentes. Para el estudio tanto farmacocin\u00e9tico como farmacodin\u00e1mico se utiliz\u00f3 la rata como animal de experimentaci\u00f3n y se clasificaron los animales en grupo control y grupo inflamaci\u00f3n (situaci\u00f3n experimental que conlleva un incremento de los seromucoides- \u00edndice de aga). As\u00ed, se realiz\u00f3 para ambos f\u00e1rmacos y en ambas situaciones un estudio de farmacocin\u00e9tica plasm\u00e1tica y de acceso a cerebro, as\u00ed como la valoraci\u00f3n del efecto analg\u00e9sico mediante el test de tail-flick y del efecto de depresi\u00f3n respiratoria, mediante la valoraci\u00f3n de los gases sangu\u00edneos. Los resultados m\u00e1s destacados son: la ausencia de repercusi\u00f3n en los efectos de la elevaci\u00f3n de los seromucoides en el caso de morfina, que acompa\u00f1a a una ausencia de variaci\u00f3n significativa en su grado de fijaci\u00f3n a prote\u00ednas plasm\u00e1ticas; la existencia de un cambio (descenso) en el efecto analg\u00e9sico de metadona cuando \u00e9sta se administra por v\u00eda intravenosa, pero no por v\u00eda subcut\u00e1nea, aunque en ambos casos el incremento en la fijaci\u00f3n en el grupo inflamaci\u00f3n fuera semejante. El menor efecto de depresi\u00f3n respiratoria tras metadona en el grupo inflamaci\u00f3n; y la dificil relaci\u00f3n entre niveles farmacol\u00f3gicos en el lugar del efecto (cerebral) y el efecto analg\u00e9sico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Fijacion a las proteinas plasmaticas de morfina y metadona y su importancia en la farmacocinetica y farmacodinamia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Fijacion a las proteinas plasmaticas de morfina y metadona y su importancia en la farmacocinetica y farmacodinamia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Gomez Iglesias <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosario Calvo Duo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Raimundo Carlos Garcia <\/li>\n<li>Elena Suarez Gonzalez (vocal)<\/li>\n<li>Africa Mediavilla Martinez (vocal)<\/li>\n<li>Alfonso Seoane Lucas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Gomez Iglesias El acceso de f\u00e1rmacos al snc est\u00e1 restringido por la existencia de la barrera [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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