{"id":36067,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activacion-miofibroblastica-de-las-celulas-estrelladas-hepaticas-durante-el-proceso-de-metastasis-del-melanoma-b16\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"activacion-miofibroblastica-de-las-celulas-estrelladas-hepaticas-durante-el-proceso-de-metastasis-del-melanoma-b16","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/activacion-miofibroblastica-de-las-celulas-estrelladas-hepaticas-durante-el-proceso-de-metastasis-del-melanoma-b16\/","title":{"rendered":"Activacion miofibroblastica de las celulas estrelladas hepaticas durante el proceso de metastasis del melanoma b16."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elvira Olaso Montero <\/strong><\/h2>\n<p>Durante el desarrollo de la met\u00e1stasis hep\u00e1tica, las c\u00e9lulas que expresan iso-alfa-actina de m\u00fasculo liso (sma) constituyen un componente importante del estroma tumoral. Sin embargo, no existe informaci\u00f3n precisa sobre su procedencia espec\u00edfica, regulaci\u00f3n y funci\u00f3n durante la progresi\u00f3n tumoral.  este trabajo demuestra la localizaci\u00f3n intrametast\u00e1sica de c\u00e9lulas que expresan sma desde estadios muy tempranos del proceso de met\u00e1stasis experimental hep\u00e1tica del melanoma b16 (mb16). Estas c\u00e9lulas con sma formaron una red estromal alrededor de las c\u00e9lulas del mb16, y expresaron microfilamentos de desmina en un porcentaje muy peque\u00f1o. Por el contrario, aquellas partes del higado que no estuvieron afectadas por met\u00e1stasis, presentaron c\u00e9lulas estrelladas hep\u00e1ticas perisinusoidales (ceh) con expresi\u00f3n de desmina, pero no de sma.  el tratamiento in vitro de cultivos de ceh recien aisladas con medio condicionado del melanoma b16 (mb16-mc) produjo un incremento progresivo (p&lt;0.01) en el n\u00famero de ceh con expresi\u00f3n de sma, asociado a una reducci\u00f3n en el n\u00famero de c\u00e9lulas con expresi\u00f3n de desmina. Asi mismo, el mb16-mc estimul\u00f3 de forma significativa (p&lt;0.01) la incorporaci\u00f3n por las ceh de (3h)-timidina y de (3h) glucosamina, as\u00ed como la secreci\u00f3n de metaloproteasas de matriz de tipo 2 y de ciertos factor(es) quimiot\u00e1cticos que produjeron un incremento en la capacidad migratoria in vitro de c\u00e9lulas de mb16.  los resultados obtenidos en el presente estudio permiten concluir que: el mb16 secreta factores que favorecen la activaci\u00f3n de las ceh. Estos factores act\u00faan mediante un mecanismo paracrino, favoreciendo la aparici\u00f3n e infiltraci\u00f3n intrametast\u00e1sica de una poblaci\u00f3n de miofibroblastos, que presentan alteraciones citoesquel\u00e9ticas asociadas a un incremento en las tasas de proliferaci\u00f3n, s\u00edntesis de glucosaminoglucanos, secreci\u00f3n de mmp-2 y producci\u00f3n de factores quimiot\u00e1cticos para el t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activacion miofibroblastica de las celulas estrelladas hepaticas durante el proceso de metastasis del melanoma b16.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activacion miofibroblastica de las celulas estrelladas hepaticas durante el proceso de metastasis del melanoma b16. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elvira Olaso Montero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Vidal Vanaclocha<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Miguel Ar\u00e9chaga Mart\u00ednez <\/li>\n<li>Manuel Jos\u00e9 Gayoso Rodriguez (vocal)<\/li>\n<li>Manuel Alvarez-uria Rico (vocal)<\/li>\n<li>Guillermo S\u00e1nchez Salgado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elvira Olaso Montero Durante el desarrollo de la met\u00e1stasis hep\u00e1tica, las c\u00e9lulas que expresan iso-alfa-actina de m\u00fasculo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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