{"id":36150,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-alfa-fetoproteina-y-la-incorporacion-del-acido-graso-docosahexenoico-en-los-mamiferos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"la-alfa-fetoproteina-y-la-incorporacion-del-acido-graso-docosahexenoico-en-los-mamiferos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-alfa-fetoproteina-y-la-incorporacion-del-acido-graso-docosahexenoico-en-los-mamiferos\/","title":{"rendered":"La alfa-fetoproteina y la incorporacion del acido graso docosahexenoico en los mamiferos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Victor Estarreado Meseguer <\/strong><\/h2>\n<p>La alfa-fetoprote\u00edna, prote\u00edna plasm\u00e1tica caracter\u00edstica del periodo fetal y neonatal en los mam\u00edferos, transporta \u00e1cidos grasos poliinsaturados y, muy particularmente, dha, \u00e1cido graso principal de la serie n-3, y componente fundamental de los l\u00edpidos estructurales del cerebro y de la retina. Existe una amplia evidencia de que el propio dha podr\u00eda ser esencial durante el desarrollo fetal y neonatal en los mam\u00edferos y en particular en el hombre, por lo que es precisa la presencia de un transportador que facilite la acreci\u00f3n este \u00e1cido graso en el cerebro en desarrollo. Se ha propuesto en diversas ocasiones que la funci\u00f3n de la afp era precisamente asegurar el transporte e incorporaci\u00f3n del dha en los l\u00edpidos cerebrales.  en el presente trabajo se ha planteado un objetivo principal: intentar correlacionar las proporciones de dha incorporados en cerebros de ratas con los niveles de afp plasm\u00e1ticos. A este fin se han dise\u00f1ado diversas estrategias para obtener ratas neonatales con una concentraci\u00f3n de afp baja. En primer lugar, se han seleccionado ratas que espont\u00e1neamente muestran una concentraci\u00f3n de afp baja (aproximadamente la mitad de la concentraci\u00f3n media presente en las ratas de su misma edad); en segundo lugar, en ratas neonatales se ha inducido una reacci\u00f3n inflamatoria mediante la inyecci\u00f3n de trementina lo que provoca una disminuci\u00f3n notable del nivel de dicha prote\u00edna; del mismo modo, se ha inducido un descenso en el nivel de afp s\u00e9rico mediante la inyecci\u00f3n del glucocorticoide dexametasona. En todos los casos estudiados, se observa una disminuci\u00f3n significativa en la proporci\u00f3n de dha incorporado en el cerebro. Este efecto podr\u00eda ser espec\u00edfico porque no se observa un cambio similar en otros pufa. Se ha estudiado tambi\u00e9n, en ratas neonatales, el efecto de la fase aguda inducida por la trementina sobre la concentraci\u00f3n de algunas prote\u00ednas plasm\u00e1ticas y sobre el metabolismo lip\u00eddico, e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La alfa-fetoproteina y la incorporacion del acido graso docosahexenoico en los mamiferos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La alfa-fetoproteina y la incorporacion del acido graso docosahexenoico en los mamiferos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Victor Estarreado Meseguer <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fermin Lampreave Palacios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Andres Pi\u00f1eiro Anton <\/li>\n<li>Jos\u00e9 Antonio Ramos Atance (vocal)<\/li>\n<li>Miguel \u00e1ngel P\u00e9rez Albarsanz (vocal)<\/li>\n<li> Garcia De Jalon Comet Angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Victor Estarreado Meseguer La alfa-fetoprote\u00edna, prote\u00edna plasm\u00e1tica caracter\u00edstica del periodo fetal y neonatal en los mam\u00edferos, transporta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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