{"id":36166,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunoquimioterapia-especifica-en-la-leishmaniosis-canina-seguimiento-inmunologico-y-entomologico\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"inmunoquimioterapia-especifica-en-la-leishmaniosis-canina-seguimiento-inmunologico-y-entomologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/inmunoquimioterapia-especifica-en-la-leishmaniosis-canina-seguimiento-inmunologico-y-entomologico\/","title":{"rendered":"Inmunoquimioterapia especifica en la leishmaniosis canina. seguimiento inmunologico y entomologico."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Guarga Penella Jos\u00e9 Luis <\/strong><\/h2>\n<p>El planteamiento de la tesis se ha centrado en la utilizaci\u00f3n de un tratamiento basado en la terapia habitualmente usada en las cl\u00ednicas veterinarias frente a la leishmaniosis canina, pero con la innovaci\u00f3n de combinar una inmunoestimulaci\u00f3n espec\u00edfica frente a l.  infantum junto al f\u00e1rmaco leishmanicida (glucantimer+ant\u00edgeno de leishmania). Al margen del seguimiento cl\u00ednico de los animales tratados, hemos realizado un seguimiento epidemiol\u00f3gico con la utilizaci\u00f3n phlebotomus perniciosus (principal vector en arag\u00f3n) tras enfrentarlos sobre los perros del estudio, pudiendo comprobar as\u00ed la infectividad de los insectos y las posibilidades de transmisi\u00f3n de la enfermedad, incluso despu\u00e9s del tratamiento. Tambi\u00e9n realizamos un estudio inmunol\u00f3gico de los animales, observando la variaci\u00f3n del t\u00edtulo de anticuerpos espec\u00edficos mediante dos t\u00e9cnicas serol\u00f3gicas (ifi y dat), junto a un estudio de la inmunidad celular, mediante la t\u00e9cnica de linfoproliferaci\u00f3n y citometr\u00eda de flujo a fin de caracterizar las subpoblaciones linfocitarias de los animales.  todos los perros tratados respondieron favorablemente a la pauta terap\u00e9utica desde un punto de vista cl\u00ednico (mejor\u00eda de la sintomatolog\u00eda y normalizaci\u00f3n del proteinograma). El estudio entomol\u00f3gico demostr\u00f3 que, al margen de la buena respuesta cl\u00ednica, los animales no dejaron de infectar al vector, lo que indica un no aclaramiento total del protozoo; salvo dos individuos que tras el tratamiento fueron incapaces de infectar flebotomos en el tiempo ocupado para el estudio. Desde el punto de vista inmunol\u00f3gico, no se detect\u00f3 una variaci\u00f3n en el t\u00edtulo de anticuerpos en ninguno de los grupos; la respuesta imune celular se caracteriz\u00f3 por un aumento de c\u00e9lulas cd4\/tcr    y cd4\/cd45ra sin mostrar una modificaciones en la poblaci\u00f3n de las cd8 en los animales tratados, mientras que en los del grupo control ocurri\u00f3 al contrario; una respuesta linfoprolifera<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunoquimioterapia especifica en la leishmaniosis canina. seguimiento inmunologico y entomologico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunoquimioterapia especifica en la leishmaniosis canina. seguimiento inmunologico y entomologico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Guarga Penella Jos\u00e9 Luis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Castillo Hernandez Juan  Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Agustin Estrada Pe\u00f1a <\/li>\n<li>Ricardo Molina Moreno (vocal)<\/li>\n<li>Jorge Alvar Ezquerra (vocal)<\/li>\n<li>Javier Moreno Nuncio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guarga Penella Jos\u00e9 Luis El planteamiento de la tesis se ha centrado en la utilizaci\u00f3n de un 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