{"id":36188,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-formas-primariamente-progresivas-de-esclerosis-multiple\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-de-las-formas-primariamente-progresivas-de-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-las-formas-primariamente-progresivas-de-esclerosis-multiple\/","title":{"rendered":"Estudio de las formas primariamente progresivas de esclerosis multiple."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Marzo Sola M. Eugenia <\/strong><\/h2>\n<p>Introducci\u00f3n: la esclerosis m\u00faltiple (em) es una enfermedad desmielinizante del snc. M\u00e1s del 70% de los pacientes presenta un curso remitente recurrente (rr); el 10-15% tiene un curso progresivo desde su inicio: em primariamente progresivas (em pp); un peque\u00f1o subgrupo, esencialmente progresivo, presenta un \u00fanico brote en su evoluci\u00f3n (em transicional). Se ha descrito que los pacientes con em pp presentan caracter\u00edsticas diferentes respecto a las formas rr, a nivel cl\u00ednico, radiol\u00f3gico ypetol\u00f3gico. La causa de la em es desconocida; se sabe que intervienen factores gen\u00e9ticos y ambientales (virus).  se considera que es una enfermedad autoinmune mediada por linfocitos t y en su patogenia tienen gran importancia las mol\u00e9culas de adhesi\u00f3n y las citocinas.  objetivo: describir las caracter\u00edsticas cl\u00ednicas, radiol\u00f3gicas (rm craneal) e inmunol\u00f3gicas de una muestra amplia de pacientes con em pp. Establecer si existen diferencias entre las formas pura y transicional.  material y m\u00e9todo: en 121 pacientes con em pp se llev\u00f3 a cabo un estudio cl\u00ednico, radiol\u00f3gico (cuantificaci\u00f3n de lesiones en rm craneal de 88 pacientes) e inmunol\u00f3gico (mediante citometr\u00eda de flujo, en 27 pacientes y 10 controles sanos, determinando los siguientes par\u00e1metros:  citocinas (il-10, il-12, ifn-y), mol\u00e9culas de adhesi\u00f3n (cd50, cd54,cd62l,cd11a, cd29, cd49d)).  resultados: ratio mujer\/hombre: 1,6; curso pp puro: 62,8% y 37,2% transicional; cl\u00ednica predominante medular: 70,2% y el 29,8% no medular; \u00edndice de progresi\u00f3n medio: 0,66, el subgrupo de pacientes con \u00edndice de progresi\u00f3n mayor fue los pacientes con em pp pura medular; la cuantificaci\u00f3n de las lesiones en la rm craneal fue inferior en los pacientes con cl\u00ednica medular, pe alterados en m\u00e1s del 80% de los pacientes; bandas oligoclonales: m\u00e1s positivas en mujeres y en pacientes con cl\u00ednica medular. Los pacientes con em pp respecto a los controles sanos presentaron niveles<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las formas primariamente progresivas de esclerosis multiple.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las formas primariamente progresivas de esclerosis multiple. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Marzo Sola M. Eugenia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Montalban Gairin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Morales Asin <\/li>\n<li>Antonio Oliveros Juste (vocal)<\/li>\n<li> Pascual Millan Luis Fernando (vocal)<\/li>\n<li>Joan Genesca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marzo Sola M. Eugenia Introducci\u00f3n: la esclerosis m\u00faltiple (em) es una enfermedad desmielinizante del snc. M\u00e1s del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,139,1880,13610],"tags":[95977,17596,95976,95978,95975,36261],"class_list":["post-36188","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-medicina-interna","category-neurologia","category-zaragoza","tag-antonio-oliveros-juste","tag-francisco-morales-asin","tag-javier-montalban-gairin","tag-joan-genesca","tag-marzo-sola-m-eugenia","tag-pascual-millan-luis-fernando"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36188","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=36188"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36188\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=36188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=36188"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=36188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}