{"id":36198,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-administracion-exogena-de-los-factores-de-crecimiento-en-la-reparacion-ulcerosa\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efecto-de-la-administracion-exogena-de-los-factores-de-crecimiento-en-la-reparacion-ulcerosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-administracion-exogena-de-los-factores-de-crecimiento-en-la-reparacion-ulcerosa\/","title":{"rendered":"Efecto de la administracion exogena de los factores de crecimiento en la reparacion ulcerosa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angeles Perez Aisa <\/strong><\/h2>\n<p>Los antinflamatorios no esteroideos (aines) retrasan la cicatrizaci\u00f3n de la \u00falcera p\u00e9ptica gastroduodenal. Los factores de crecimiento s\u00f3los o combinados con f\u00e1rmacos antisecretores ser\u00edan capaces de revertir este efecto.  objetivo: 1.- Estudiar el efecto de los aines (indometacina) en la din\u00e1mica de cicatrizaci\u00f3n de la \u00falcera cr\u00f3nica duodenal en un modelo experimental animal.  2.- Evaluar el efecto de los factores de crecimiento (tgf-beta, egf, pdgf) y de un antisecretor (famotidina) y de sus posibles combinaciones, en la din\u00e1mica de reparaci\u00f3n de las \u00falceras duodenales asociadas a indometacina. 3.- Estudiar si los efectos de estos agentes sobre la reparaci\u00f3n se asocia a la modulaci\u00f3n de la secreci\u00f3n g\u00e1strica, proliferaci\u00f3n celular o a componentes de la matriz extracelular. Material y metodos: experimentos in vivo sobre un modelo de \u00falcera cr\u00f3nica duodenal en ratas donde se evaluar\u00e1n par\u00e1metros macrosc\u00f3picos, microsc\u00f3picos, proliferaci\u00f3n celular, secreci\u00f3n \u00e1cido-p\u00e9ptica y secreci\u00f3n de col\u00e1geno por parte del tejido de granulaci\u00f3n. Se administra: indometacina (ind)=2 mg\/kg\/d\u00eda v\u00eda intramuscular, famotidina (fam)= 1 mg\/kg\/d\u00eda v\u00eda intramuscular, tgf-beta= 15 ng por \u00falcera v\u00eda subserosa en el momento de inducci\u00f3n de la \u00falcera, pdgf= 30 ng\/100g\/d\u00eda mediante sondaje orog\u00e1strico, egf= 50ug\/kg\/d\u00eda mediante sondaje orog\u00e1strico. Estudios in vitro sobre cultivo de fibroblastos g\u00e1stricos y de piel de origen humano donde se valorar\u00e1 la secreci\u00f3n de col\u00e1geno mediante la incorporaci\u00f3n de prolina tritiada a las prote\u00ednas totales y al col\u00e1geno seg\u00fan los factores administrados: aas e ind= 10-4 a 10-5 m, pge1 10-6 a 10-8 m, egf= 10 ng\/ml, tgf-beta= 120 pg\/ml, 1 ng\/ml, pdgf= 3 ng\/ml. Resultados: la administraci\u00f3n de los factores de crecimiento y la famotidina aceler\u00e1n y reviertenel efecto de la indometacina en el proceso de reparaci\u00f3n. S\u00f3lo la combinaci\u00f3n de tgf-beta con famotidina mejoralos pa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la administracion exogena de los factores de crecimiento en la reparacion ulcerosa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la administracion exogena de los factores de crecimiento en la reparacion ulcerosa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angeles Perez Aisa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Lanas Arbeloa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Javier Ortego Fernandez De Retana <\/li>\n<li>Miguel Bixquert Jimenez (vocal)<\/li>\n<li>Jos\u00e9 Ram\u00f3n Morandeira Garc\u00eda- Lacruz (vocal)<\/li>\n<li>Vicente Garrigues Gil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angeles Perez Aisa Los antinflamatorios no esteroideos (aines) retrasan la cicatrizaci\u00f3n de la \u00falcera p\u00e9ptica gastroduodenal. Los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,13610],"tags":[28606,95997,45551,95998,19302,78618],"class_list":["post-36198","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-zaragoza","tag-angel-lanas-arbeloa","tag-angeles-perez-aisa","tag-javier-ortego-fernandez-de-retana","tag-jose-ramon-morandeira-garcia-lacruz","tag-miguel-bixquert-jimenez","tag-vicente-garrigues-gil"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36198","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=36198"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36198\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=36198"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=36198"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=36198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}