{"id":36239,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":""},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efectos-centrales-y-perifericos-de-los-antihistaminicos-comparacion-entre-hidroxizina-cetirizina-terfenadina-y-loratadina-mediante-respuesta-cutanea-a-la-histamina-rendimiento-psicomotor-evaluaci","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-centrales-y-perifericos-de-los-antihistaminicos-comparacion-entre-hidroxizina-cetirizina-terfenadina-y-loratadina-mediante-respuesta-cutanea-a-la-histamina-rendimiento-psicomotor-evaluaci\/","title":{"rendered":"Efectos centrales y perifericos de los antihistaminicos: comparacion entre hidroxizina, cetirizina, terfenadina y loratadina mediante respuesta cutanea a la histamina, rendimiento psicomotor, evaluaciones subjetivas y f-eeg-c."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Antonijoan Arbos Rosa M. <\/strong><\/h2>\n<p>La administraci\u00f3n de antihistam\u00ednicos h1 normalmente se asocia a sedaci\u00f3n y deterioro en la ejecuci\u00f3n conductual, aunque la intensidad y duraci\u00f3n de estos efectos indeseables var\u00edan entre f\u00e1rmacos y sujetos.  en un estudio de fase i, doble-ciego, aleatorizado, cruzado y controlado con placebo, 16 sujetos j\u00f3venes sanos de ambos sexos recibieron dosis orales \u00fanicas \u00abterap\u00e9uticamente equivalentes\u00bb de cetirizina 10mg (ctz), terfenadina 120mg (tfd) y loratadina 10mg (lor) utiliz\u00e1ndose hidroxizina 25mg (hxz) como est\u00e1ndar positivo. Las evaluaciones incluyeron: a) actividad perif\u00e9rica, tanto antihistam\u00ednica (\u00abprick test\u00bb y efecto subjetivo) como anticolin\u00e9rgica (secreci\u00f3n salival espont\u00e1nea); b) actividad sobre el snc mediante pruebas objetivas conductuales (frecuencia cr\u00edtica de fusi\u00f3n-centelleo, tiempo simple de reacci\u00f3n, test de cancelaci\u00f3n \u00abd2\u00bb test motricidad fina), escalas de valoraci\u00f3n subjetiva (anal\u00f3gicas y num\u00e9ricas) y registros neurofisiol\u00f3gicos (16 canales de eeg, eog vertical y horizontal, con los ojos cerrados) cuantific\u00e1ndose seg\u00fan cartograf\u00eda topogr\u00e1fica de la f\u00e1rmaco-eeg- cuantitativa e \u00edndices de vigilancia; y c) tolerabilidad. Tales evaluaciones se llevaron a nivel basal y a + 1, +2, +4, +6 y +8 horas postmedicaci\u00f3n.  todos los tratamientos activos presentaron actividad antihistam\u00ednica h1 perif\u00e9rica. Esta actividad fue m\u00e1xima para hxz y ctz, menor para lor e intermedia para tfd. No se observaron diferencias entre los distintos tratamientos en la evaluaci\u00f3n de la actividad anticolin\u00e9rgica perif\u00e9rica. La evaluaci\u00f3n del efecto sobre el snc en las diferentes pruebas objetivas de rendimiento psicomotor mostr\u00f3 ausencia de cambios significativos tras ctz, ter y lor, en comparaci\u00f3n a placebo, mientras que hxz produjo deterioros manifiestos.  las escalas de evaluaci\u00f3n subjetiva mostraron que si bien hxz produc\u00eda la mayor sensaci\u00f3n subjetiva de sedaci\u00f3n, ctz, ter y lor tambi\u00e9n pud<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos centrales y perifericos de los antihistaminicos: comparacion entre hidroxizina, cetirizina, terfenadina y loratadina mediante respuesta cutanea a la histamina, rendimiento psicomotor, evaluaciones subjetivas y f-eeg-c.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos centrales y perifericos de los antihistaminicos: comparacion entre hidroxizina, cetirizina, terfenadina y loratadina mediante respuesta cutanea a la histamina, rendimiento psicomotor, evaluaciones subjetivas y f-eeg-c. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Antonijoan Arbos Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel J Barbanoj Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francesc Jan\u00e9 Carrenca <\/li>\n<li>M. Eulalia Planas  Domingo (vocal)<\/li>\n<li>Francisco Javier Galiana Martinez (vocal)<\/li>\n<li>Agust\u00edn Alomar Munta\u00f1ola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonijoan Arbos Rosa M. La administraci\u00f3n de antihistam\u00ednicos h1 normalmente se asocia a sedaci\u00f3n y deterioro en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957,183],"tags":[72744,96071,51,10859,13850,14229],"class_list":["post-36239","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-farmacos-psicotropicos","tag-agustin-alomar-muntanola","tag-antonijoan-arbos-rosa-m","tag-francesc-jane-carrenca","tag-francisco-javier-galiana-Martinez","tag-m-eulalia-planas-domingo","tag-manuel-j-barbanoj-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=36239"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36239\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=36239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=36239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=36239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}