{"id":36309,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-las-metalotioneinas-hepaticas-y-cerebrales\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"regulacion-de-las-metalotioneinas-hepaticas-y-cerebrales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/regulacion-de-las-metalotioneinas-hepaticas-y-cerebrales\/","title":{"rendered":"Regulacion de las metalotioneinas hepaticas y cerebrales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joaquim Hernandez Martin <\/strong><\/h2>\n<p>Se ha estudiado principalmente la regulaci\u00f3n de las metalotione\u00ednas (mts) por glucocorticoides y citocinas en h\u00edgado y cerebro, tanto de rata como de rat\u00f3n, durante situaciones fisiol\u00f3gicas como la inflamaci\u00f3n y el estr\u00e9s.  los glucocorticoides muestran un papel regulador del mrna y de la prote\u00edna de las mts durante el estr\u00e9s en rat\u00f3n pero no en rata. Gracias a la cesi\u00f3n de diversas cepas de ratones knock-outs, como el del gen de la il-6, el tnf-alfar1 y el ifn-gammar hemos estudiado el papel de las citocinas en estas situaciones. As\u00ed, durante el estr\u00e9s, la il-6 regula la inducci\u00f3n de las mts hep\u00e1ticas.  por otro lado hemos comprobado que la il-6 y el tnf-alfa regulan las mts hep\u00e1ticas durante la inflamaci\u00f3n. En cerebro, los glucocorticoides regulan la respuesta al estr\u00e9s del mrna y de la prote\u00edna de las mt(i+ii) mientras que la mt-iii muestra un patr\u00f3n diferencial de regulaci\u00f3n. En situaciones de inflamaci\u00f3n, las mt(i+ii) se encuentran incrementadas, tanto por administraciones agudas de endotoxina como en un modelo animal cr\u00f3nico de inflamaci\u00f3n (gfap-il6). La mt-iii muestra un patr\u00f3n diferencial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de las metalotioneinas hepaticas y cerebrales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de las metalotioneinas hepaticas y cerebrales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joaquim Hernandez Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Hidalgo Pareja<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jordi Balasch <\/li>\n<li>Pilar Gonzalez Duarte (vocal)<\/li>\n<li>Luis Paternain Jose (vocal)<\/li>\n<li>Silvia Atrian Ventura (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joaquim Hernandez Martin Se ha estudiado principalmente la regulaci\u00f3n de las metalotione\u00ednas (mts) por glucocorticoides y citocinas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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