{"id":36372,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-preliminar-de-la-aplicacion-oftalmica-de-hibridos-de-cecropina-a-y-melitina-como-antimicrobianos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"evaluacion-preliminar-de-la-aplicacion-oftalmica-de-hibridos-de-cecropina-a-y-melitina-como-antimicrobianos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/evaluacion-preliminar-de-la-aplicacion-oftalmica-de-hibridos-de-cecropina-a-y-melitina-como-antimicrobianos\/","title":{"rendered":"Evaluacion preliminar de la aplicacion oftalmica de hibridos de cecropina a y melitina como antimicrobianos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Morilla Grasa <\/strong><\/h2>\n<p>En este trabajo se ha evaluado la posible aplicaci\u00f3n oft\u00e1lmica de p\u00e9ptidos h\u00edbridos de cecropina y melitina como antimicrobianos. El objetivo planteado fue el de reducir el tama\u00f1o de sus precursores naturales manteniendo o aumentando su actividad antimicrobiana y disminuyendo su toxicidad. Para la consecuci\u00f3n de este objetivo se realizaron pruebas de actividad in vitro, valoraci\u00f3n de la cmi (concentraci\u00f3n m\u00ednima inhibitoria) frente a un amplio espectro bacteriano. De los p\u00e9ptidos evaluados se seleccionaron los m\u00e1s activos y \u00e9stos fueron probados frente a hongos (valoraci\u00f3n de cmi frente a candida albicans) y posteriormente su actividad in vivo.  para la realizaci\u00f3n de la actividad in vivo se utiliz\u00f3 un modelo de queratitis experimental bacteriana en conejo albino. La toxicidad in vitro se evalu\u00f3 mediante el test del mtt (mide actividad enzim\u00e1tica mitocondrial), mientras que la toxicidad in vivo se evalu\u00f3 mediante el test de draize o tolerancia ocular aguda (toa). Los p\u00e9ptidos seleccionados resultaron ser activos frente a hongos. No se observaron efectos t\u00f3xicos en las c\u00e9lulas epiteliocorneales de conejo. Mostraron diferencia significativa (p -&lt; 0.05) entre el grupo control y gentamicina \/ciprofloxacina \/grupo de p\u00e9ptidos en la valoraci\u00f3n cl\u00ednica que se realiz\u00f3 en los experimentos de actividad in vivo, aunque en algunos casos se observ\u00f3 un efecto inflamatorio inherente a los p\u00e9ptidos. Este efecto secundario fue ratificado por los experimentos de toxicidad in vivo donde al evaluarse el \u00edndice de irritaci\u00f3n ocular mediante examen cl\u00ednico se determin\u00f3 que los p\u00e9ptidos eran \u00abligera o moderadamente t\u00f3xicos\u00bb.  las conclusiones de este trabajo reflejan un tama\u00f1o cr\u00edtico de los p\u00e9ptidos h\u00edbridos de cecropina a y melitina de 11 amino\u00e1cidos y que es necesaria la presencia de cuatro cargas positivas en la mol\u00e9cula. El espectro de actividad se extiende a hongos. No se observan efectos t\u00f3xicos frente<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluacion preliminar de la aplicacion oftalmica de hibridos de cecropina a y melitina como antimicrobianos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluacion preliminar de la aplicacion oftalmica de hibridos de cecropina a y melitina como antimicrobianos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Morilla Grasa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Salvador Nos Barbera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Albert Badia <\/li>\n<li>Josep Guasch (vocal)<\/li>\n<li>Carlos Pastor Jose (vocal)<\/li>\n<li>Mar\u00eda Herreras Jose (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Morilla Grasa En este trabajo se ha evaluado la posible aplicaci\u00f3n oft\u00e1lmica de p\u00e9ptidos h\u00edbridos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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