{"id":36414,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-acido-linoleico-de-la-dieta-sobre-la-hiperplasia-intimal-inducida-en-modelos-experimentales\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efectos-del-acido-linoleico-de-la-dieta-sobre-la-hiperplasia-intimal-inducida-en-modelos-experimentales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-del-acido-linoleico-de-la-dieta-sobre-la-hiperplasia-intimal-inducida-en-modelos-experimentales\/","title":{"rendered":"Efectos del acido linoleico de la dieta sobre la hiperplasia intimal inducida en modelos experimentales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente Riambau Alonso <\/strong><\/h2>\n<p>Introducci\u00f3n: la hiperplasia intimal (hi) limita el \u00e9xito de las t\u00e9cnicas revascularizadoras. Todav\u00eda no se conoce con exactitud el complejo mecanismofisiopatol\u00f3gico de la hi. Consecuentemente, no se dispone de m\u00e9todos preventivos eficaces y seguros.  antecedentes: el metabolismo de los \u00e1cidos grasos interviene en las interacciones fisiopatol\u00f3gicas entre la sangre y la pared vascular. La prostaciclina (pgi2), vasodilatador y antigregante, y el \u00e1cido 15-hidroxieicosatetraenoico (15-hete), mitog\u00e9nico y quimiot\u00e1ctico, son producidos por la pared vascular a partir del \u00e1cido araquid\u00f3nico (aa). Tambi\u00e9n, las c\u00e9lulas vasculares sintetizan un metabolito del \u00e1cido linol\u00e9ico (al), el \u00e1cido 13-hidroxioctadecadienoico (13-hode) que aumenta la tromborresistencia de la pared vascular.  adem\u00e1s, el \u00e1cido linoleico reduce el colesterol plasm\u00e1tico y aumenta la fracci\u00f3n hdl.  hip\u00f3tesis: las dietas enriquecidas con al pueden reducir la formaci\u00f3n de hi y de aterosclerosis mediante un incremento de s\u00edntesis de 13-hode y de pgi2, y una disminuci\u00f3n del 15-hete y una correcci\u00f3n beneficiosa de los l\u00edpidos plasm\u00e1ticos.  objetivos: i) confeccionar un modelo animal v\u00e1lido para evaluar las modificaciones bioqu\u00edmicas de los metabolitos 13-hode, pgi2 y 15-hete y \u00fatil para crear lesi\u00f3n vascular y posterior desarrollo de hi. Ii) evaluar el efecto biol\u00f3gico de dietas enriquecidas con al sobre la hi despu\u00e9s de una lesi\u00f3n endotelial y su correlaci\u00f3n con el contenido vascular de pgi2, 15-hete y 13-hode y con los l\u00edpidos plasm\u00e1ticos.  material y m\u00e9todos: se dise\u00f1aron tres estudios experimentales distribuidos en tres fases. Fase i:  estudio experimental, observacional, ex vivo, comparativo con autocontrol. Se seleccionaron 10 conejos blancos de nueva zelanda a los que les fueron extraidos ambas car\u00f3tidas, ambas venas yugulares, la aorta tor\u00e1cica y abdominal y la vena cava inferior. Se analizaron las producciones basales y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del acido linoleico de la dieta sobre la hiperplasia intimal inducida en modelos experimentales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del acido linoleico de la dieta sobre la hiperplasia intimal inducida en modelos experimentales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente Riambau Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Rius Cornado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Eduardo Ros Die <\/li>\n<li>Jaime Mulet Melia (vocal)<\/li>\n<li>Emilio Viver Manresa (vocal)<\/li>\n<li>Luis Vila Navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Riambau Alonso Introducci\u00f3n: la hiperplasia intimal (hi) limita el \u00e9xito de las t\u00e9cnicas revascularizadoras. Todav\u00eda no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,1279,1550],"tags":[1555,91620,96425,13187,96424,9781],"class_list":["post-36414","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","category-cirugia-vascular","tag-eduardo-ros-die","tag-emilio-viver-manresa","tag-jaime-mulet-melia","tag-luis-vila-navarro","tag-vicente-riambau-alonso","tag-xavier-rius-cornado"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=36414"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36414\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=36414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=36414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=36414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}