{"id":36441,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-endotelina-1-en-la-fisiopatologia-del-vasoespasmo-cerebral-post-hemorragia-subaracnoidea\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"papel-de-la-endotelina-1-en-la-fisiopatologia-del-vasoespasmo-cerebral-post-hemorragia-subaracnoidea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-la-endotelina-1-en-la-fisiopatologia-del-vasoespasmo-cerebral-post-hemorragia-subaracnoidea\/","title":{"rendered":"Papel de la endotelina-1 en la fisiopatolog\u00eda del vasoespasmo cerebral post-hemorragia subaracnoidea."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Secades Ruiz Julio Jose <\/strong><\/h2>\n<p>Se han analizado secuencialmente los niveles plasm\u00e1ticos de endotelina 1 (et-1) en 17 pacientes afectos de hemorragia subaracnoidea aneurism\u00e1tica. Se trata de 4 varones y 13 mujeres, con una edad media de 48.1 +- 20.3 a\u00f1os, que ingresaron en un estado cl\u00ednico aceptable (hunt-hess 4, escala de coma de glasgow10) y a los que se realiz\u00f3 un examen neurorradiol\u00f3gico completo y se pudo realizar la determinaci\u00f3n de et-1 en los intervalos previstos de tiempo. La cantidad de sangre visible en la tomograf\u00eda computerizada se catalog\u00f3 usando la escala de fisher. Se determinaron los niveles normales de et-1 en un grupo de voluntarios sanos, resultando ser de 6.48 +- 1.42 pg\/ml.  en los pacientes con hemorragia subaracnoidea, los niveles plasm\u00e1ticos de et-1 se encuentran significativamente (p=0.024) en la 2a. Semana tras el sangrado, en comparaci\u00f3n con los valores normales obtenidos. Los pacientes que desarrollaron vasoespasmo cerebral sintom\u00e1tico o deterioro neurol\u00f3gico isqu\u00e9mico diferido (dnid) tienen unos niveles plasm\u00e1ticos de et-1 significativamente (p=0.034) superiores y con una evoluci\u00f3n temporal significativamente (p=0.0146) diferente en comparaci\u00f3n con los pacientes que no desarrollan esta complicaci\u00f3n.  tambi\u00e9n hemos encontrado una correlaci\u00f3n significativa (p=0.02) entre los niveles plasm\u00e1ticos basales de et-1 y el resultado final valorado con la escala de recuperaci\u00f3n de glasgow (gos).  el an\u00e1lisis de regresi\u00f3n m\u00faltiple demuestra que existe una dependencia estad\u00edsticamente significativa entre los niveles plasm\u00e1ticos de et-1 y la clasificaci\u00f3n seg\u00fan la escala de fisher (p=0.0195), el desarrollo de dnid (p=0.0095) y el resultado final valorado con la gos (p=0.0319).  el an\u00e1lisis de regresi\u00f3n log\u00edstica encuentra una interrelaci\u00f3n predictiva, con un poder del 74.24%, entre la clasificaci\u00f3n de la escala de fisher y los niveles plasm\u00e1ticos de et-1 para predecir el desarrollo de dnid (p=0.0148).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la endotelina-1 en la fisiopatolog\u00eda del vasoespasmo cerebral post-hemorragia subaracnoidea.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la endotelina-1 en la fisiopatolog\u00eda del vasoespasmo cerebral post-hemorragia subaracnoidea. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Secades Ruiz Julio Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Rubio Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miquel Vilardell Tarres <\/li>\n<li>Jorge Vilalta Castan (vocal)<\/li>\n<li>Pedro Quesada (vocal)<\/li>\n<li>F\u00e9lix Gaston Fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Secades Ruiz Julio Jose Se han analizado secuencialmente los niveles plasm\u00e1ticos de endotelina 1 (et-1) en 17 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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