{"id":36446,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/relevancia-del-citocromo-p450-en-el-metabolismo-de-xenobioticos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"relevancia-del-citocromo-p450-en-el-metabolismo-de-xenobioticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/relevancia-del-citocromo-p450-en-el-metabolismo-de-xenobioticos\/","title":{"rendered":"Relevancia del citocromo p450 en el metabolismo de xenobioticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Solans Laque Anna M. <\/strong><\/h2>\n<p>Durante los estudios de farmacocin\u00e9tica y tolerancia de dosis repetidas de furafilina -f\u00e1rmaco dise\u00f1ado como sustituto terap\u00e9utico de la teofilina- aparecieron efectos t\u00f3xicos a causa de la acumulaci\u00f3n de la cafe\u00edna propia de la dieta. La acci\u00f3n inhibitoria de la furafilina sobre el metabolismo de la cafe\u00edna se confirm\u00f3 posteriormente en estudios in vitro y en modelos animales. Estudios previos suger\u00edan la participaci\u00f3n del isoenzima 1a2 del citocromo p450 (cyp1a2) en este proceso.  posteriores estudios efectuados in vitro y en modelos animales demostraron la capacidad de la furafilina para inhibir la reacci\u00f3n de o-desetilaci\u00f3n de la fenacetina, reacci\u00f3n representativa de la actividad del isoenzima cyp1a2. Una vez refrendada la furafilina como inhibidor selectivo y espec\u00edfico de esta actividad, se utiliz\u00f3 para establecer la intervenci\u00f3n del isoenzima cyp1a2 en el metabolismo de la cafe\u00edna y en el de determinadas aminas arom\u00e1ticas heteroc\u00edclicas cuyo metabolismo genera productos con actividad carcinog\u00e9nica.  el inter\u00e9s del estudio del cyp1a2 radica en su participaci\u00f3n en la activaci\u00f3n de determinadas sustancias promut\u00e1genas a sus metabolitos genot\u00f3xicos y, al mismo tiempo, en la existencia de una gran variabilidad poblacional en cuanto a su actividad, que podr\u00eda originar diferencias en la susceptibilidad al desarrollo de procesos cancer\u00edgenos. La cafe\u00edna supon\u00eda la posibilidad de utilizar una sustancia inocua para el estudio poblacional de esta actividad enzim\u00e1tica.  los objetivos de esta tesis fueron establecer la participaci\u00f3n del isoenzima 1a2 en el metabolismo de determinados xenobi\u00f3ticos in vivo y en humanos, mediante el uso de un inhibidor espec\u00edfico de este isoenzima: la furafilina. En concreto, se estudiaron el metabolismo de la fenacetina y cafe\u00edna, as\u00ed como dos de las aminas arom\u00e1ticas m\u00e1s comunes en la dieta: el melqx y el phip.  el estudio se bas\u00f3 en dos ensayos cl\u00ednicos en f<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Relevancia del citocromo p450 en el metabolismo de xenobioticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Relevancia del citocromo p450 en el metabolismo de xenobioticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Solans Laque Anna M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael De La Torre Fornell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Margarita Arboix Arbo <\/li>\n<li>Antonio Martinez Tobet (vocal)<\/li>\n<li>Jordi Camarasa Garcia (vocal)<\/li>\n<li>Angel Messeguer Peypoch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Solans Laque Anna M. Durante los estudios de farmacocin\u00e9tica y tolerancia de dosis repetidas de furafilina -f\u00e1rmaco [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[339,9,189,957,17648],"tags":[18986,96486,55612,5678,81519,96485],"class_list":["post-36446","post","type-post","status-publish","format-standard","hentry","category-analisis-de-farmacos","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-procesos-metabolicos-de-los-farmacos","tag-angel-messeguer-peypoch","tag-antonio-Martinez-tobet","tag-jordi-camarasa-garcia","tag-margarita-arboix-arbo","tag-rafael-de-la-torre-fornell","tag-solans-laque-anna-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36446","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=36446"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36446\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=36446"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=36446"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=36446"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}