{"id":36465,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunohistoquimico-de-la-expresion-de-la-oncoproteina-c-erbb-2-en-cancer-de-prostata-significado-pronostico\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-inmunohistoquimico-de-la-expresion-de-la-oncoproteina-c-erbb-2-en-cancer-de-prostata-significado-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-inmunohistoquimico-de-la-expresion-de-la-oncoproteina-c-erbb-2-en-cancer-de-prostata-significado-pronostico\/","title":{"rendered":"Estudio inmunohistoquimico de la expresion de la oncoproteina c-erbb-2 en cancer de prostata: significado pronostico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Vallejo Gil <\/strong><\/h2>\n<p>La expresi\u00f3n del oncogen c-erbb-2 ha sido demostrada en diversas neoplasias humanas. Este oncogen situado a nivel del cromosoma 17 q 21, codifica una prote\u00edna de membrana de 185.000 daltons (p185). La determinaci\u00f3n de la expresi\u00f3n de esta prote\u00edna en las muestras de tejido de determinados procesos neopl\u00e1sicos se ha relacionado con un peor pron\u00f3stico. Se analiza la expresi\u00f3n de esta prote\u00edna en tejido prost\u00e1tico normal, en hiperplasia benigna y en carcinoma prost\u00e1tico, y se relaciona esta expresi\u00f3n con diversas variables pron\u00f3sticas.  material y m\u00e9todos se evalua la expresi\u00f3n de la prote\u00edna de membrana c-erbb-2 (p185), mediante tinci\u00f3n con anticuerpos monoclonales ncl-cb11 (c-erbb-2), en 125 muestras de c\u00e1ncer prost\u00e1tico obtenidas mediante biopsia prost\u00e1tica y rtu, en 18 casos de hiperplasia benigna prost\u00e1tica y en 4 de pr\u00f3stata normal. La inmunoreactividad se cuantific\u00f3 utilizando el analizador de imagen olympus cue-2 con software para an\u00e1lisis en blanco y negro.  conclusiones &#8211; no se ha detectado expresi\u00f3n de la prote\u00edna c-erbb-2 de membrana en el tejido prost\u00e1tico normal, hall\u00e1ndose en el 11% de las muestras con hiperplasia benigna de pr\u00f3stata y en el 60% de las muestras con c\u00e1ncer prost\u00e1tico.  &#8211; en los pacientes con c\u00e1ncer prost\u00e1tico, no se ha observado relaci\u00f3n significativa entre la expresi\u00f3n de la prote\u00edna c-erbb-2 de membrana y la edad, estad\u00edo cl\u00ednico, grado de diferenciaci\u00f3n histol\u00f3gico ni severidad de la enfermedad metast\u00e1sica \u00f3sea.  &#8211; se ha encontrado una relaci\u00f3n significativa entre la expresi\u00f3n proteica de c-erbb-2 y la elevada concentraci\u00f3n s\u00e9rica de psa en el momento del diagn\u00f3stico de la enfermedad (p&lt;0,05).  &#8211; no se ha observado relaci\u00f3n significativa entre la expresi\u00f3n de la prote\u00edna c-erbb-2 y el tipo de respuesta cl\u00ednica inicial en pacientes sometidos a hormonoterapia.  &#8211; en pacientes con c\u00e1ncer de pr\u00f3stata sometidos a hormonoterapia y globalmente c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio inmunohistoquimico de la expresion de la oncoproteina c-erbb-2 en cancer de prostata: significado pronostico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunohistoquimico de la expresion de la oncoproteina c-erbb-2 en cancer de prostata: significado pronostico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Vallejo Gil <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Morote Robles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Quesada Marin <\/li>\n<li>Jaume Reventos Puigjaner (vocal)<\/li>\n<li>Josep Lloreta Trull (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Vallejo Gil La expresi\u00f3n del oncogen c-erbb-2 ha sido demostrada en diversas neoplasias humanas. Este oncogen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,347,971],"tags":[96520,34115,53909,84108,1458],"class_list":["post-36465","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-oncologia-clinica","category-urologia","tag-carlos-vallejo-gil","tag-jaume-reventos-puigjaner","tag-josep-lloreta-trull","tag-juan-morote-robles","tag-pedro-quesada-marin"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36465","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=36465"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36465\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=36465"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=36465"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=36465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}