{"id":36479,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-tgf-1-sobre-la-produccion-de-proteoglicanos-en-celulas-de-origen-neuroectodermico\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efectos-del-tgf-1-sobre-la-produccion-de-proteoglicanos-en-celulas-de-origen-neuroectodermico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efectos-del-tgf-1-sobre-la-produccion-de-proteoglicanos-en-celulas-de-origen-neuroectodermico\/","title":{"rendered":"Efectos del tgf-1 sobre la produccion de proteoglicanos en celulas de origen neuroectodermico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joan Villena Garcia <\/strong><\/h2>\n<p>El factor de transformaci\u00f3n beta (tgf-beta) desempe\u00f1a un papel importante en la regulaci\u00f3n de la matriz extracelular y como modulador de la proliferaci\u00f3n y diferenciaci\u00f3n de muchos tipos celulares. En este trabajo, hemos estudiado los efectos del tgf-beta1 sobre la proliferaci\u00f3n, la formaci\u00f3n de colonias en agar blando y la s\u00edntesis de proteoglicanos en tres l\u00edneas celulares de melanoma humano (sk-mel-1.36-1-5, sk-mel-3.44 y sk-mel-23), una de astrocitoma (u-251) y una de neuroblastoma (sk-nsh).  el tgf-beta1 inhibe la proliferaci\u00f3n y el crecimiento en agar blando en todas las l\u00edneas estudiadas con la excepci\u00f3n de la l\u00ednea celular de melanoma sk-mel-23, en la que en general el tgf-beta1 no presenta efectos.  el tgf-beta1 incrementa la liberaci\u00f3n de proteoglicanos al medio extracelular, entre ellos el proteoglicano espec\u00edfico de melanoma mel-cspg y un nuevo proteoglicano denominado por nosotros pg-l (\u00ablarge proteoglycan\u00bb). Este factor modifica la composici\u00f3n de disac\u00e1ridos y la sulfataci\u00f3n de las cadenas de glicosaminoglicanos.  el efecto m\u00e1s importante es el incremento del \u00abshedding\u00bb de mel-cspg al medio tal y como hemos observado mediante experimentos de \u00abpulse-chase\u00bb, sin verse afectados los niveles de proteoglicano unido a membrana ni el balance entre la forma de proteoglicano y la forma glicoproteica del mel-cspg.  la caracterizaci\u00f3n del proteoglicano mel-cspg purificado de c\u00e9lulas control y tratadas con tgf-beta1 indica que el factor incrementa ligeramente la longitud y el n\u00famero de cadenas de gags presentes en este proteoglicano.  obtuvimos resultados similares con el nuevo proteoglicano pg-l.  en todos los casos el efecto del tgf-beta1 es m\u00e1s pronunciado en la l\u00ednea celular menos diferenciada sk-mel-1.36-1-5 que en la l\u00ednea celular sk-mel-3.44, mientras que no tiene efecto alguno sobre la l\u00ednea celular m\u00e1s diferenciada sk-mel-23.  el tgf-beta1 tambi\u00e9n inhibe la proliferaci\u00f3n en las l\u00edn<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del tgf-1 sobre la produccion de proteoglicanos en celulas de origen neuroectodermico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del tgf-1 sobre la produccion de proteoglicanos en celulas de origen neuroectodermico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joan Villena Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Anna Mar\u00eda Bassols Teixido<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Senen Vilar\u00f3 Coma <\/li>\n<li>Francesc Ventura Pujol (vocal)<\/li>\n<li>Angels Fabra Fres (vocal)<\/li>\n<li>Carles Ar\u00fas Caralt\u00f3 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joan Villena Garcia El factor de transformaci\u00f3n beta (tgf-beta) desempe\u00f1a un papel importante en la regulaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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