{"id":36487,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-sobre-derivados-de-oligosacaridos-de-interes-biologico-sintesis-de-un-tioanalogo-del-trisacarido-lewis-x-y-otras-estructuras-relacionadas\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudios-sobre-derivados-de-oligosacaridos-de-interes-biologico-sintesis-de-un-tioanalogo-del-trisacarido-lewis-x-y-otras-estructuras-relacionadas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudios-sobre-derivados-de-oligosacaridos-de-interes-biologico-sintesis-de-un-tioanalogo-del-trisacarido-lewis-x-y-otras-estructuras-relacionadas\/","title":{"rendered":"Estudios sobre derivados de oligosacaridos de interes biologico: sintesis de un tioanalogo del trisacarido lewis x y otras estructuras relacionadas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Aguilera Diez M. Bego\u00f1a <\/strong><\/h2>\n<p>El primer aspecto abordado en la memoria presentada consisti\u00f3 en la s\u00edntesis de un an\u00e1logo m\u00e1s estable del trisac\u00e1rido lewis x, en el que las unidades de fucosa y n-acetilglucosamina se encuentran unidas por un \u00e1tomo de azufre en lugar del \u00e1tomo de ox\u00edgeno. Se estudiaron dos rutas sint\u00e9ticas diferentes hacia el tiotrisac\u00e1rido objetivo. En ambas aproximaciones sint\u00e9ticas, la construcci\u00f3n del enlace tioglicos\u00eddico se efectu\u00f3 mediante la reacci\u00f3n de apertura nucle\u00f3fila de un sulfamidato c\u00edclico, derivado de un monosac\u00e1rido o disac\u00e1rido, siendo \u00e9sta la primera vez que se presenta la s\u00edntesis y reacciones de este tipo de derivados a partir de yb carbohidrato. Asimismo se llev\u00f3 a cabo un estudio de la reactividad de un sulfamidato c\u00edclico derivado de alosamina frente a nucle\u00f3filos de diversa naturaleza.  en segundo lugar, se realiz\u00f3 el estudio conformacional comparativo de disac\u00e1rido fuc a(1-3) glcnac, fragmento del lewis x, y su tiodisac\u00e1rido an\u00e1logo. El an\u00e1lisis se llev\u00f3 a cabo mediante c\u00e1lculos de mec\u00e1nica molecular y experimentos de resonancia magn\u00e9tica nuclear.  el tercer y \u00faltimo objetivo consisti\u00f3 en la s\u00edntesis de varias series de derivados de disac\u00e1ridos, estructuralmente relacionados con el lewis x, como potenciales inhibidores de la mitosis de c\u00e9lulas tumorales gliales humanas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios sobre derivados de oligosacaridos de interes biologico: sintesis de un tioanalogo del trisacarido lewis x y otras estructuras relacionadas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios sobre derivados de oligosacaridos de interes biologico: sintesis de un tioanalogo del trisacarido lewis x y otras estructuras relacionadas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Aguilera Diez M. Bego\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>mayoralas \u00e1lvarez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Garc\u00eda Ruano <\/li>\n<li>Francisco Santoyo Gonz\u00e1lez (vocal)<\/li>\n<li>Ernesto Suarez L\u00f3pez (vocal)<\/li>\n<li>Jos\u00e9 Cristobal L\u00f3pez P\u00e9rez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aguilera Diez M. Bego\u00f1a El primer aspecto abordado en la memoria presentada consisti\u00f3 en la s\u00edntesis de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17,416],"tags":[96571,9943,10976,24741,5621,29927],"class_list":["post-36487","post","type-post","status-publish","format-standard","hentry","category-quimica","category-quimica-organica","tag-aguilera-diez-m-begona","tag-ernesto-suarez-lopez","tag-francisco-santoyo-gonzalez","tag-jose-cristobal-lopez-perez","tag-jose-luis-garcia-ruano","tag-mayoralas-alvarez-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36487","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=36487"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36487\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=36487"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=36487"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=36487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}