{"id":36489,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/dolor-en-la-pancreatitis-cronica-papel-de-los-acidos-biliares-y-de-la-colecistoquinina-plasmatica\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"dolor-en-la-pancreatitis-cronica-papel-de-los-acidos-biliares-y-de-la-colecistoquinina-plasmatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/dolor-en-la-pancreatitis-cronica-papel-de-los-acidos-biliares-y-de-la-colecistoquinina-plasmatica\/","title":{"rendered":"Dolor en la pancreatitis cronica. papel de los acidos biliares y de la colecistoquinina plasmatica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Alba Martin <\/strong><\/h2>\n<p>Hipotesis y objetivos: la liberaci\u00f3n de colecistoquinina (cck) plasm\u00e1tica est\u00e1 regulada mediante un mecanismo de retroalimentaci\u00f3n negativa dependiente del nivel intraduodenal de tripsina y \u00e1cidos biliares. El dolor en la pancreatitis cr\u00f3nica est\u00e1 relacionado con el aumento de presi\u00f3n intraductal y la elevaci\u00f3n del nivel plasm\u00e1tico de cck incrementa la secreci\u00f3n pancre\u00e1tica acumulada sobre conductos previamente alterados aumentando la presi\u00f3n intraductal, con lo que finalmente se genera dolor. Se propone como hip\u00f3tesis que la liberaci\u00f3n intraduodenal defectuosa de tripsina y\/o \u00e1cidos biliares (ab) en pacientes con pancreatitis cr\u00f3nica incrementar\u00eda el nivel plasm\u00e1tico de cck e inducir\u00eda dolor. El objetivo fundamental es determinar los niveles basales y postprandiales de tripsina y \u00e1cidos biliares intraduodenales y de cck plasm\u00e1tica en pacientes con pancreatitis cr\u00f3nica y relaci\u00f3n con la presencia de dolor.  pacientes y m\u00e9todos: se estudiaron 20 pacientes diagnosticados de pc por cuadro cl\u00ednico compatible y hallazgos espec\u00edficos en, al menos, dos de las t\u00e9cnicas de imagen (eco, tac y pre). En ausencia de expresi\u00f3n cl\u00ednica, fue necesaria la demostraci\u00f3n de d\u00e9ficit exocrino mediante pruebas de funci\u00f3n pancre\u00e1tica. Los pacientes se estratificaron en dos grupos atendiendo a la presencia de dolor abdominal (grupo i) o ausencia de dolor (grupo ii).  las determinaciones principales fueron tripsina y ab en jugo duodenal y cck en sangre. Se determinaron para cada par\u00e1metro niveles basales y a los 30, 60 y 90 minutos tras estimulaci\u00f3n con comida.  resultados: el nivel intraduodenal de tripsina es significativamente inferior en los pacientes con dolor s\u00f3lo a 30 y 90 minutos tras estimulaci\u00f3n, respecto a los pacientes sin dolor. El nivel intraduodenal de ab se halla significativamente disminuido en los pacientes con dolor (grupo i) en todos los tiempos (basal y estimulados). El nivel plasm\u00e1tico de cck<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dolor en la pancreatitis cronica. papel de los acidos biliares y de la colecistoquinina plasmatica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dolor en la pancreatitis cronica. papel de los acidos biliares y de la colecistoquinina plasmatica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Alba Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jos\u00e9 V\u00e1zquez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Rodr\u00edguez Montes <\/li>\n<li>Jos\u00e9 Miguel Cano L\u00f3pez (vocal)<\/li>\n<li>\u00e1ngel Del Palacio P\u00e9rez-medel (vocal)<\/li>\n<li> Carballo Lopez Luis Fernando (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Alba Martin Hipotesis y objetivos: la liberaci\u00f3n de colecistoquinina (cck) plasm\u00e1tica est\u00e1 regulada mediante un mecanismo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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