{"id":36525,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-y-alteraciones-del-gen-de-la-beta-catenina-en-carcinomas-de-ovario-en-estadio-i-y-ii\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-de-la-expresion-y-alteraciones-del-gen-de-la-beta-catenina-en-carcinomas-de-ovario-en-estadio-i-y-ii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-expresion-y-alteraciones-del-gen-de-la-beta-catenina-en-carcinomas-de-ovario-en-estadio-i-y-ii\/","title":{"rendered":"Estudio de la expresion y alteraciones del gen de la beta-catenina en carcinomas de ovario en estadio i y ii."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Calvo De Mora Alvarez Jorge <\/strong><\/h2>\n<p>Durante el proceso de embriog\u00e9nesis y en el mantenimiento funcional y estructural de los tejidos ya diferenciados, es esencial la integridad de la adhesi\u00f3n celular. Existen m\u00faltiples evidencias experimentales de la existencia de alteraciones en la adhesi\u00f3n intercelular en diferentes tipos tumorales. Una de las familias de mol\u00e9culas de adhesi\u00f3n m\u00e1s trascendentes en estos procesos son las cadherinas. B-catenina es una prote\u00edna que se encuentra formando parte junto a la cadherina-e y a otras prote\u00ednas, como alfa-catenina,   -catenina (plakoglobina) y p120cas, de los complejos cadherina\/cateninas. La funci\u00f3n de la beta-catenina no se restringe a la participaci\u00f3n en los procesos de adhesi\u00f3n celular sino que tambi\u00e9n est\u00e1 implicada en los mecanismos motilidad celular y en la traducci\u00f3n de se\u00f1ales al n\u00facleo celular, en el que participan mol\u00e9culas de beta catenina libres en el citoplasma, que asoci\u00e1ndose a prote\u00ednas de la familia tcf-lef tienen capacidad de desplazarse al n\u00facleo y unirse al adn para activar la transcripci\u00f3n de genes a\u00fan no identificados. En los paises industrializados, el c\u00e1ncer de ovario es la neoplasia del aparato genital femenino que causa m\u00e1s muertes, siendo el 90% de ellos tumores derivados del epitelio cel\u00f3mico. Los estudios de beta-catenina en este modelo tumoral son pr\u00e1cticamente inexistentes.  hemos estudiado 100 pacientes con tumores epiteliales (carcinomas y tumores borderline) de ovario en estadios i y ii de la f.I.G.O. Analizando en ellos la expresi\u00f3n de beta-catenina. Las alteraciones en esta expresi\u00f3n se han correlacionado con otros factores cl\u00ednicos (edad y estadio), patol\u00f3gicos (tipo histol\u00f3gico y grado) y con la expresi\u00f3n de cd-e, p53, c-erbb-2, bcl-2 y de ki-67. En un grupo de casos se ha secuenciado el ex\u00f3n 3 del gen de la beta-catenina (ctnnb1). Adem\u00e1s hemos correlacionado todos estos par\u00e1metros con la supervivencia de las pacientes.  en nuestra serie el patr\u00f3n de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la expresion y alteraciones del gen de la beta-catenina en carcinomas de ovario en estadio i y ii.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresion y alteraciones del gen de la beta-catenina en carcinomas de ovario en estadio i y ii. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Calvo De Mora Alvarez Jorge <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Gamallo Amat<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Felix Contreras Rubio <\/li>\n<li>Jos\u00e9 Mar\u00eda Rivera Pomar (vocal)<\/li>\n<li>Antonio Gonzalez Gonzalez (vocal)<\/li>\n<li> Martinez Tello Francisco Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Calvo De Mora Alvarez Jorge Durante el proceso de embriog\u00e9nesis y en el mantenimiento funcional y estructural [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,52,156,384],"tags":[4193,96632,14769,15008,13350,92554],"class_list":["post-36525","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-histopatologia","category-patologia","category-patologia-clinica","tag-antonio-gonzalez-gonzalez","tag-calvo-de-mora-alvarez-jorge","tag-carlos-gamallo-amat","tag-felix-contreras-rubio","tag-jose-maria-rivera-pomar","tag-Martinez-tello-francisco-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36525","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=36525"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/36525\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=36525"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=36525"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=36525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}