{"id":36534,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-del-gen-de-prolactina-por-ligandos-de-receptores-nucleares-y-de-receptores-tirosina-quinasa\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"regulacion-de-la-expresion-del-gen-de-prolactina-por-ligandos-de-receptores-nucleares-y-de-receptores-tirosina-quinasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/regulacion-de-la-expresion-del-gen-de-prolactina-por-ligandos-de-receptores-nucleares-y-de-receptores-tirosina-quinasa\/","title":{"rendered":"Regulacion de la expresion del gen de prolactina por ligandos de receptores nucleares y de receptores tirosina quinasa."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Castillo Varon Ana Isabel <\/strong><\/h2>\n<p>En esta tesis hemos abordado el estudio de la expresi\u00f3n del gen de prolactina (prl) por el receptor del factor de crecimiento igf-1, un receptor de membrana con actividad tirosina quinasa y por los receptores nucleares para la vitamina d3 (vdr) y los proliferadores de proxisomas (ppar).  hemos encontrado que igf-1 regula de forma diferente la expresi\u00f3n de los genes de prl, gh y ghf-1 en las lineas celulares hipofisarias gh3 y gh4c1. En las c\u00e9lulas gh3, igf-1 inhibe la expresi\u00f3n del gen de ghf-1, lo que produce un nivel de prote\u00edna ghf-1 que es insuficiente para permitir la activaci\u00f3n del promotor de prl. Por el contrario, en las c\u00e9lulas gh4c1 los niveles de expresi\u00f3n de ghf-1 no se ven afectados por igf-1, y este factor de crecimiento act\u00faa activando el promotor de prl. En esta l\u00ednea celular, igf-1 activa la ruta de pi3k y la de ras\/mapk\/ets. Estas rutas act\u00faan conjuntamente para activar el promotor de prl. La presencia de ghf-1 es esencial para la activaci\u00f3n del promotor de prl por los receptores nucleares vdr y ppar. Estos receptores activan el promotor de prl de forma diferente. Vdr ejerce su acci\u00f3n mediante la uni\u00f3n a una secuencia localizada entre -45\/-27 en la regi\u00f3n 5 flanqueante, mientras que ppar activa el promotor a trav\u00e9s de interacciones prote\u00edna-prote\u00edna.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de la expresion del gen de prolactina por ligandos de receptores nucleares y de receptores tirosina quinasa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de la expresion del gen de prolactina por ligandos de receptores nucleares y de receptores tirosina quinasa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Castillo Varon Ana Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Aranda Iriarte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Enrique Aguilar Benitez De Lugo <\/li>\n<li>Gregorio Angel Santos Montes (vocal)<\/li>\n<li>Alberto Mu\u00f1oz Terol (vocal)<\/li>\n<li>Francesc Villarroya Gombau (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Castillo Varon Ana Isabel En esta tesis hemos abordado el estudio de la expresi\u00f3n del gen de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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