{"id":36566,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-regulacion-transcripcional-del-gen-apoe-y-su-relacion-con-la-enfermedad-de-alzheimer\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"mecanismos-de-regulacion-transcripcional-del-gen-apoe-y-su-relacion-con-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-de-regulacion-transcripcional-del-gen-apoe-y-su-relacion-con-la-enfermedad-de-alzheimer\/","title":{"rendered":"Mecanismos de regulacion transcripcional del gen apoe y su relacion con la enfermedad de alzheimer."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Garcia Miguel Angel <\/strong><\/h2>\n<p>Las variantes al\u00e9licas -491a y -427c del promotor del gen apoe est\u00e1n asociadas a un aumento en el riesgo de padecer la enfermedad de alzheimer de tipo senil en la poblaci\u00f3n espa\u00f1ola.  las variantes al\u00e9licas traen consigo variaciones en la actividad transcripcional del promotor en c\u00e9lulas de astrocitoma. Existe una correlaci\u00f3n directa entre el riesgo de padecer la enfermedad y la actividad transcripcional de estas variantes.  hemos desarrollado un modelo matem\u00e1tico que permite estimar la preValencia de la ea en funci\u00f3n de la edad, del alelo apoe4 y tipo de promotor apoe.  la prote\u00edna cbf-a se une a la regi\u00f3n del polimorfismo -219.  el camp y el \u00e1cido retinoico regulan el promotor apoe en c\u00e9lulas de astrocitoma a trav\u00e9s del factor de transcripci\u00f3n ap-2.  la fosforilaci\u00f3n de la serina 239 del ap-2 por la pka regula la actividad del factor en respuesta a un aumento intracelular de camp.  la serina 258 del ap-2 es necesaria para la uni\u00f3n del factor al dna y para ejercer su efecto estimulador de la transcripci\u00f3n.  los oncogenes set y dek interaccionan in vitro con el ap-2.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de regulacion transcripcional del gen apoe y su relacion con la enfermedad de alzheimer.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de regulacion transcripcional del gen apoe y su relacion con la enfermedad de alzheimer. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Garcia Miguel Angel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Vazquez Cobos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Medina Jimenez <\/li>\n<li>Angel Pascual Garc\u00eda (vocal)<\/li>\n<li>Jes\u00fas Avila De Grado (vocal)<\/li>\n<li>Carlos Gabriel De Miguel Vazquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Garcia Miguel Angel Las variantes al\u00e9licas -491a y -427c del promotor del gen apoe est\u00e1n asociadas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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