{"id":36568,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-evaluacion-de-un-modelo-experimental-que-reproduce-el-patron-de-extension-locorregional-del-cancer-de-colon-humano\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"desarrollo-y-evaluacion-de-un-modelo-experimental-que-reproduce-el-patron-de-extension-locorregional-del-cancer-de-colon-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-y-evaluacion-de-un-modelo-experimental-que-reproduce-el-patron-de-extension-locorregional-del-cancer-de-colon-humano\/","title":{"rendered":"Desarrollo y evaluacion de un modelo experimental que reproduce el patron de extension locorregional del cancer de colon humano."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Garcia Rivas <\/strong><\/h2>\n<p>El modelo experimental ortot\u00f3pico sing\u00e9nico de c\u00e1ncer de colon en roedores ha sido utilizado para el estudio del proceso metast\u00e1sico, pero llama la atenci\u00f3n la ausencia de la descripci\u00f3n de la extensi\u00f3n locorregional, objetivo principal de este trabajo de investigaci\u00f3n.  para el desarrollo del modelo se han inoculado, en la pared del ciego, 1 x 10 elevado a 6 c\u00e9lulas dhd\/k12 trb en 62 ratas bd ix de 6 semanas de edad. Esta inoculaci\u00f3n intraparietal produjo en la mayor\u00eda de los casos (80,6%) un hab\u00f3n, indicando que la suspensi\u00f3n celular quedaba en el espesor de la pared. Los animales se distribuyeron de forma aleatoria en 6 grupos atendiendo a la semana en que deb\u00edan ser sacrificados (semanas: 1, 2, 4, 6, 8 y 16 respectivamente).  las variables estudiadas fueron el peso del animal, sexo, aparici\u00f3n o no de hab\u00f3n, existencia o no de tumor primario, di\u00e1metro del mismo, existencia de otros tumores en el ciego, el patr\u00f3n bioquimico y del examen microsc\u00f3pico se valor\u00f3 la localizaci\u00f3n del tumor primario, invasi\u00f3n tumoral de cada una de las capas de la pared del ciego (mucosa, muscular y serosa), salida del tumor a peritoneo, invasi\u00f3n de vasos linf\u00e1ticos y sangu\u00edneos, afectaci\u00f3n de ganglios linf\u00e1ticos, existencia de tumor en otros \u00f3rganos abdominales y existencia o no de met\u00e1stasis en t\u00f3rax.  la aparici\u00f3n de hab\u00f3n en la inoculaci\u00f3n ortot\u00f3pica mostr\u00f3 relaci\u00f3n estad\u00edsticamente significativa con la aparici\u00f3n de tumor local (p&lt;0,001). Se encontr\u00f3 tumor en 45 de los 62 animales, lo que representa un 72,6%. El di\u00e1metro medio del tumor local fue progresivamente mayor en cada uno de los grupos, siendo 0,23 cm para el grupo i y 1,64 cm en el grupo vi. El tumor local se localiz\u00f3 mayoritariamente en la submucosa (82,2%). Cinco de los 45 animales con tumor primario presentaron m\u00e1s de un tumor en el ciego o en su meso. La carcinomatosis peritoneal apareci\u00f3 en un total de 15 animales, de los cuales 9 pert<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y evaluacion de un modelo experimental que reproduce el patron de extension locorregional del cancer de colon humano.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y evaluacion de un modelo experimental que reproduce el patron de extension locorregional del cancer de colon humano. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Garcia Rivas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Damian Garc\u00eda Olmo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Garcia  Sancho Martin <\/li>\n<li>Javier Cerdan Miguel (vocal)<\/li>\n<li> Lopez Fando De Castro Javier (vocal)<\/li>\n<li>Jes\u00fas Culebras Fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Garcia Rivas El modelo experimental ortot\u00f3pico sing\u00e9nico de c\u00e1ncer de colon en roedores ha sido utilizado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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