{"id":36603,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-mecanismo-de-adhesion-celular-mediado-por-el-factor-j\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-del-mecanismo-de-adhesion-celular-mediado-por-el-factor-j","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-del-mecanismo-de-adhesion-celular-mediado-por-el-factor-j\/","title":{"rendered":"Estudio del mecanismo de adhesion celular mediado por el factor j."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Larrucea Bilbao <\/strong><\/h2>\n<p>El factor j (fj) es un inhibidor del complemento que act\u00faa sobre la v\u00eda cl\u00e1sica y la v\u00eda alternativa. Hemos demostrado mediante citometr\u00eda de flujo que el fj soluble interacciona con las l\u00edneas celulares jurkat, k562 y jy y tambi\u00e9n con diferentes poblaciones leucocitarias. El fj inmovilizado en placas de pl\u00e1stico es capaz de inducir la adhesi\u00f3n de estas c\u00e9lulas. La especificidad se demuestra mediante el bloqueo de esta interacci\u00f3n con un anticuerpo monoclonal anti-fj y con el fj soluble. La adhesi\u00f3n tiene lugar a 37 c. Pero no a 4 c y es inhibida por la citocalasina b, el nocodazol y la 2-do-glucosa y azida s\u00f3dica. Los glicosaminoglicanos como la heparina, el hepar\u00e1n sulfato y los condroit\u00edn sulfato a, b y c inhiben la uni\u00f3n celular al fj, as\u00ed como el tratamiento con condroitinasa abc. Hemos aislado el receptor del fj por cromatograf\u00eda de afinidad, cuya secuenciaci\u00f3n lo ha identificado como la nucleolina. La interacci\u00f3n de la nucleolina purificada con el fj se ha demostrado por ensayos de elisa y ligand-blot. La nucleolina purificada y un anticuerpo monoclonal antinucleolina inhiben la interacci\u00f3n celular al fj inmovilizado. El fj es internalizado por las c\u00e9lulas tras incubaci\u00f3n a 37 c. La uni\u00f3n de las c\u00e9lulas al fj induce la fosforilaci\u00f3n en tirosina de varias prote\u00ednas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del mecanismo de adhesion celular mediado por el factor j.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del mecanismo de adhesion celular mediado por el factor j. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Larrucea Bilbao <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Margarita Lopez Trascasa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Ort\u00edz De Land\u00e1zuri Busca <\/li>\n<li>Joaqu\u00edn Teixid\u00f3 Calvo (vocal)<\/li>\n<li>Carlos Caba\u00f1as Gutierrez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Larrucea Bilbao El factor j (fj) es un inhibidor del complemento que act\u00faa sobre la v\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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