{"id":36708,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-los-genes-mat2a-metionina-adenosil-transferasa-ii-y-s-adenosilmetionina-descarboxilasa-en-el-ciclo-celular-de-linfocitos-t-de-rata\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"expresion-de-los-genes-mat2a-metionina-adenosil-transferasa-ii-y-s-adenosilmetionina-descarboxilasa-en-el-ciclo-celular-de-linfocitos-t-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/expresion-de-los-genes-mat2a-metionina-adenosil-transferasa-ii-y-s-adenosilmetionina-descarboxilasa-en-el-ciclo-celular-de-linfocitos-t-de-rata\/","title":{"rendered":"Expresion de los genes mat2a (metionina adenosil transferasa ii) y s-adenosilmetionina descarboxilasa en el ciclo celular de linfocitos t de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Tobe\u00f1a Santamaria <\/strong><\/h2>\n<p>La regulaci\u00f3n de la expresi\u00f3n del gen de la mat ii fue estudiada en el ciclo celular de linfocitos t, tanto en la transici\u00f3n g0\/g1 como en g1\/s. El tratamiento de linfocitos quiescentes con con a o pdbu\/ion\u00f3foro de ca elevado a 2+ induce el mrna de la mat ii. La il-2 incrementa los niveles de mensajero en linfoblasto t en g1 as\u00ed como la actividad de la mat ii, en parte aumentando la transcripci\u00f3n del gen. El pdbu, tambi\u00e9n capaz de inducir la proliferaci\u00f3n de linfoblastos, muestra una cin\u00e9tica similar de inducci\u00f3n de mensajero y actividad. Ambos est\u00edmulos no modifican los niveles de mrna de la adohcy hidrolasa, otro enzima del ciclo de la metionina. La dex y el 8br-camp, inhibidores de la proliferaci\u00f3n linfocitaria, son capaces de bloquear la acumulaci\u00f3n de mrna de la mat ii e inhibir la actividad mat, inducida por il-2 o pdbu. Todos estos resultados sugieren que la expresi\u00f3n del gen de la mat ii est\u00e1 sujeta a una regulaci\u00f3n estrechamente relacionada con el ciclo celular de las c\u00e9lulas t.  tambi\u00e9n hemos investigado la regulaci\u00f3n de la expresi\u00f3n del gen de la adometdc, aunque centr\u00e1ndonos en la transici\u00f3n g1\/s de linfoblastos t. La il-2 y el pdbu inducen el mensajero de la adometdc, probablemente aumentando la transcripci\u00f3n del gen. La il-2 no afecta a la eficiencia de traducci\u00f3n del mrna. Los niveles de transcrito son tambi\u00e9n regulados por la concentraci\u00f3n intracelular de poliaminas. La chx superinduce la acumulaci\u00f3n de mrna de la adometdc inducida por il-2 o pdbu. El oa tambi\u00e9n provoca la inducci\u00f3n del mrna de la adometdc, indicando que las serina\/treonina prote\u00edna fosfatasas juegan un papel en su regulaci\u00f3n. Dependiendo de la se\u00f1al extracelular usada el transcrito de la adometdc exhibe diferente estabilidad. Todos estos datos sugieren que los linfoblastos t pueden utilizar m\u00faltiples v\u00edas de transducci\u00f3n de se\u00f1ales para regular los niveles de mrna de la adometdc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion de los genes mat2a (metionina adenosil transferasa ii) y s-adenosilmetionina descarboxilasa en el ciclo celular de linfocitos t de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion de los genes mat2a (metionina adenosil transferasa ii) y s-adenosilmetionina descarboxilasa en el ciclo celular de linfocitos t de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Tobe\u00f1a Santamaria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Susana Alemany De La Pe\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Emilio Feliu Albi\u00f1ana <\/li>\n<li> Pajares Tarancon Mar\u00eda  De Los Angeles (vocal)<\/li>\n<li>Margarita Fern\u00e1ndez Garc\u00eda De Castro (vocal)<\/li>\n<li>Fernando Jos\u00e9 Corrales Izquierdo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Tobe\u00f1a Santamaria La regulaci\u00f3n de la expresi\u00f3n del gen de la mat ii fue estudiada en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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