{"id":37037,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/apoptosis-tumoral-relacion-con-la-proliferacion-indice-mitotico-ki67-y-genes-reguladores-p53-c-erb-2-prediccion-de-respuesta-a-la-irradiacion-y-supervivencia\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"apoptosis-tumoral-relacion-con-la-proliferacion-indice-mitotico-ki67-y-genes-reguladores-p53-c-erb-2-prediccion-de-respuesta-a-la-irradiacion-y-supervivencia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/apoptosis-tumoral-relacion-con-la-proliferacion-indice-mitotico-ki67-y-genes-reguladores-p53-c-erb-2-prediccion-de-respuesta-a-la-irradiacion-y-supervivencia\/","title":{"rendered":"Apoptosis tumoral: relacion con la proliferacion (indice mitotico, ki67) y genes reguladores (p53, c-erb-2). prediccion de respuesta a la irradiacion y supervivencia."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Perez Correa Sofia Elena <\/strong><\/h2>\n<p>La apoptosis es una forma de muerte celular, con rasgos morfol\u00f3gicos caracter\u00edsticos, gen\u00e9ticamente modulada, y esencial en el desarrollo y homeostasis de los tejidos maduros. Es de especial inter\u00e9s su papel en la g\u00e9nesis de enfermedad. La determinaci\u00f3n de la tasa de apoptosis, y su posible valor pron\u00f3stico en el c\u00e1ncer, fue el objeto de nuestro estudio actual. Determinamos el \u00edndice apopt\u00f3tico (ia), tumores de cuatro localizaciones diferentes, (c\u00e1ncer de mama, urotelio superior, laringe y vejiga) e investigamos si exist\u00eda relaci\u00f3n entre la tasa de apoptosis y factores histol\u00f3gicos cl\u00e1sicos de pron\u00f3stico, genes reguladores de apoptosis-proliferaci\u00f3n celular, supervivencia y respuesta a la radioterapia.  inicialmente analizamos 128 casos de carcinoma de mama encontrando relaci\u00f3n directa y significativa entre ia y proliferaci\u00f3n (\u00edndice mit\u00f3tico -im- y expresi\u00f3n de ki67), grado, extensi\u00f3n local, ganglionar, extracapsular ganglionar, vascular, sobrexpresi\u00f3n de p53 y ausencia de receptores estrog\u00e9nicos. No hubo relaci\u00f3n entre ia y sobreexpresi\u00f3n de c-erb-2, ni receptores progester\u00f3nicos.  no dispon\u00edamos de seguimiento cl\u00ednico suficiente por lo que proyectamos un segundo estudio, en 92 casos de carcinoma de urotelio superior tratados quir\u00fargicamente.  observamos que los pacientes con tumores con un ia bajo o medio, ten\u00edan mejor supervivencia que los que ten\u00edan un ia alto (p&lt;0,053). Se mantuvo la relaci\u00f3n directa entre alta apoptosis y proliferaci\u00f3n (im y ki67), grado, estadio, extensi\u00f3n local, ganglionar y vascular. No se encontr\u00f3 relaci\u00f3n estad\u00edsticamente significativa entre \u00edndice apopt\u00f3tico y sobreexpresi\u00f3n de p53. Un aspecto clave del papel pron\u00f3stico de la apoptosis es su relaci\u00f3n con la respuesta a la radioterapia, por lo que, en una tercera fase, analizamos 57 casos de carcinoma de laringe tratados mediante cirug\u00eda y radioterapia postoperatoria.  el ia se relacion\u00f3, adem\u00e1s de co<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Apoptosis tumoral: relacion con la proliferacion (indice mitotico, ki67) y genes reguladores (p53, c-erb-2). prediccion de respuesta a la irradiacion y supervivencia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Apoptosis tumoral: relacion con la proliferacion (indice mitotico, ki67) y genes reguladores (p53, c-erb-2). prediccion de respuesta a la irradiacion y supervivencia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Perez Correa Sofia Elena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Lara Jimenez Pedro Carlos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Vicente Pedraza Muriel <\/li>\n<li>C. Begg Adrian (vocal)<\/li>\n<li>Claudio Antonio Oton Sanchez (vocal)<\/li>\n<li> Coco Martin Jos\u00e9 Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Perez Correa Sofia Elena La apoptosis es una forma de muerte celular, con rasgos morfol\u00f3gicos caracter\u00edsticos, gen\u00e9ticamente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,1027,347,16629,156],"tags":[97524,8162,97525,97523,97522,3714],"class_list":["post-37037","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-oncologia","category-oncologia-clinica","category-palmas-de-gran-canaria","category-patologia","tag-c-begg-adrian","tag-claudio-antonio-oton-sanchez","tag-coco-martin-jose-manuel","tag-lara-jimenez-pedro-carlos","tag-perez-correa-sofia-elena","tag-vicente-pedraza-muriel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37037","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37037"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37037\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}