{"id":3719,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/eficacia-de-la-rifampicina-y-doxiciclina-en-el-tratamiento-de-la-brucelosis-humana\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"eficacia-de-la-rifampicina-y-doxiciclina-en-el-tratamiento-de-la-brucelosis-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/eficacia-de-la-rifampicina-y-doxiciclina-en-el-tratamiento-de-la-brucelosis-humana\/","title":{"rendered":"Eficacia de la rifampicina y doxiciclina en el tratamiento de la brucelosis humana."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Solera Santos <\/strong><\/h2>\n<p>En un ensayo clinico, comparativo, multicentrico y abierto se demuestra que la combinacion de rifampicina y doxiciclina durante 45 dias es menos eficaz que la asociacion clasica de estreptomicina y doxiciclina administrada la primera 14 dias y la segunda 45, en el tratamiento de la brucelosis humana. La aparicion de recidivas es significativamente mayor en el grupo tratado con rifampicina y doxiciclina (rr 2,93; ic 95% 1,12-7,67; p=0,03). Los fallos terapeuticos iniciales son mas frecuentes con la asociacion de rifampicina y doxiciclina y se presentan en pacientes con enfermedad focal, especialmente con espondilodiscitis. El numero de efectos secundarios es similar y los dos tratamientos se toleran bien. El numero de pacientes considerados curados es significativamente menor en los pacientes tratados con rifampicina y doxiciclina (rr 0,81;ic 95%0,71-0,93;p=0,0032).  el meta-analisis de los 8 ensayos publicados muestra que la combinacion de rifampicina y doxiciclina es menos eficaz que la pauta clasica cuando se valora el numero de recidivas y el de curaciones. El numero de recidivas en los pacientes tratados con estreptomicina y doxiciclina es muy similar en los 8 estudios y no difiere entre los que administran la estreptomicina 14 o 21 dias y la doxiciclina u otra tetraciclina 30 o 45 dias. Sin embargo, los pacientes a los que se administro la rifampicina junto a la doxiciclina 30 o 21 dias presentaron recidivas entre el 29 y 39% mientras que cuando se administro 45 dias esta pauta el numero de recidivas era de 5 al 13%. La recomendacion del comite de expertos en brucelosis de la fao\/oms emitida en su sexto informe de 1986 de que la pauta de rifampicina y doxiciclina es mas eficaz que la asociacion de estreptomicina y doxiciclina es insostenible con los datos aportados por el ensayo clinico y el meta-analisis de los ensayos publicados hasta octubre de 1983.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Eficacia de la rifampicina y doxiciclina en el tratamiento de la brucelosis humana.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Eficacia de la rifampicina y doxiciclina en el tratamiento de la brucelosis humana. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Solera Santos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Del Rey Calero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Javier Lopez Fando <\/li>\n<li>Rafael Hernuzo Cabrera (vocal)<\/li>\n<li>Manuel Fernandez Guerrero (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Solera Santos En un ensayo clinico, comparativo, multicentrico y abierto se demuestra que la combinacion de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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