{"id":37260,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anticuerpos-monoclonales-cd3-caracterizacion-de-sus-sitios-de-union\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"anticuerpos-monoclonales-cd3-caracterizacion-de-sus-sitios-de-union","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/anticuerpos-monoclonales-cd3-caracterizacion-de-sus-sitios-de-union\/","title":{"rendered":"Anticuerpos monoclonales cd3: caracterizacion de sus sitios de union."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Andrade Lillo Winston Socrates <\/strong><\/h2>\n<p>No se conoce el sitio de uni\u00f3n de los anticuerpos monoclonales anti-cd3 a pesar de su amplio uso cl\u00ednico.  se ha demostrado que el anticuerpo anti-cd3 7d6 reconoce un determinante alot\u00edpico en cd3 de rat\u00f3n y no se reconoce cd3-epsilon por s\u00ed solo, si no que reconoce solo el m\u00f3dulo cd3-epsilongamma y no el cd3-epsilon d. Por secuenciaci\u00f3n y transfecci\u00f3n en c\u00e9lulas cos, hemos demostrado que el cambio de solo un amino\u00e1cido, la asn89 lys89 en la regi\u00f3n extracelular de cd3-epsilon de rat\u00f3n es responsable del reconocimiento alot\u00edpico de 7d6 y la variaci\u00f3n de este amino\u00e1cido define dos alelos para cd3-epsilon de rat\u00f3n. Un panel de seis anticuerpos monoclonales anti-cd3 de rat\u00f3n tambi\u00e9n reconocen m\u00f3dulos y no subunidades aisladas en transfectantes de c\u00e9lulas cos, aunque no discriminan entre cd3-epsilon gamma y cd3-epsilon d. El no reconocimiento de subunidades aisladas podr\u00eda deberse a un control de plegamiento de cd3-epsilon. En un modelo bi y tridimensional de cd3-epsilon, el amino\u00e1cido asn89 se ubica en un giro beta extracelular muy expuesto, que si es sustituido se pierde la uni\u00f3n de todos los anticuerpos anti-cd-3. Todos los anticuerpos anti-cd3 de rat\u00f3n analizados compiten entre s\u00ed por la uni\u00f3n a cd3-epsilon.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Anticuerpos monoclonales cd3: caracterizacion de sus sitios de union.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Anticuerpos monoclonales cd3: caracterizacion de sus sitios de union. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Andrade Lillo Winston Socrates <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio De La Hera Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Merino Perez <\/li>\n<li>Augusto Silva Gonzalez (vocal)<\/li>\n<li>Africa Gonzalez Fernandez (vocal)<\/li>\n<li>Eduardo Reyes Martin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andrade Lillo Winston Socrates No se conoce el sitio de uni\u00f3n de los anticuerpos monoclonales anti-cd3 a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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