{"id":37281,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/test-de-liberacion-de-histamina-en-el-diagnostico-de-hipersensibilidad-a-betalactamicos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"test-de-liberacion-de-histamina-en-el-diagnostico-de-hipersensibilidad-a-betalactamicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/test-de-liberacion-de-histamina-en-el-diagnostico-de-hipersensibilidad-a-betalactamicos\/","title":{"rendered":"Test de liberacion de histamina en el diagnostico de hipersensibilidad a betalactamicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Diaz Donado <\/strong><\/h2>\n<p>Los antibi\u00f3ticos betalact\u00e1micos son los agentes antimicrobianos de uso m\u00e1s extendido debido a su eficacia terap\u00e9utica y a su escasa toxicidad. Sin embargo, constituyen la causa m\u00e1s frecuente de reacci\u00f3n adversa medicamentosa mediada por un mecanismo inmunol\u00f3gico. Las pruebas cut\u00e1neas con betalact\u00e1micos constituyen la mejor t\u00e9cnica diagn\u00f3stica con la que contamos en la actualidad para el estudio de los pacientes con sospecha de reacci\u00f3n al\u00e9rgica tras la administraci\u00f3n de penicilina y derivados. La existencia de un resultado positivo establece el diagn\u00f3stico de forma fehaciente, sin embargo, un resultado negativo implica la prosecuci\u00f3n del estudio con la administraci\u00f3n controlada de betalact\u00e1micos. La determinaci\u00f3n de la ige espec\u00edfica en suero para betalact\u00e1micos a\u00f1adida a las pruebas cut\u00e1neas no supone un incremento significativo de la sensibilidad diagn\u00f3stica. En otras patolog\u00edas al\u00e9rgicas, asma por \u00e1caros, alergia alimentaria el test de liberaci\u00f3n de histamina por bas\u00f3filos ha mostrado resultados muy alentadores. Mediante la utilizaci\u00f3n de 40 pacientes diagnosticados de hipersensibilidad a betalact\u00e1micos y con 64 sujetos control se ha estimado el valor diagn\u00f3stico del test de liberaci\u00f3n de histamina (tlh) en el diagn\u00f3stico de hipersensibilidad a betalact\u00e1micos. Se ha realizado el tlh para tres ant\u00edgenos: penicilina g, amoxicilina y ampicilina. Simult\u00e1neamente, se realizaron pruebas cut\u00e1neas con ppl, mdm, penicilina g, amoxicilina y ampicilina, as\u00ed como determinaci\u00f3n de ige espec\u00edfica en suero mediante cap para bencipeniciloil, amoxicilina y ampicilina con objeto de comparar la nueva t\u00e9cnica con las ya universalmente aceptadas. Los resultados obtenidos muestran para el tlh con betalact\u00e1micos par\u00e1metros de sensibilidad, especificidad, vpp y vpn inferiores a los encontrados para las pruebas cut\u00e1neas con betalact\u00e1micos y similares a los par\u00e1metros calculados para el cap con btls. Destaca<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Test de liberacion de histamina en el diagnostico de hipersensibilidad a betalactamicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Test de liberacion de histamina en el diagnostico de hipersensibilidad a betalactamicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Diaz Donado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Melchor Alvarez De Mon Soto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Felix Lorente Toledano <\/li>\n<li> Davila Gonzalez Jos\u00e9 Ignacio (vocal)<\/li>\n<li>Santiago Quirce Gancedo (vocal)<\/li>\n<li>Manuela Cuevas Agustin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Diaz Donado Los antibi\u00f3ticos betalact\u00e1micos son los agentes antimicrobianos de uso m\u00e1s extendido debido a su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,2193,35,4111,1737,278],"tags":[97918,97919,14979,97920,14431,31737],"class_list":["post-37281","post","type-post","status-publish","format-standard","hentry","category-alcala","category-antibioticos","category-ciencias-de-la-vida","category-hipersensibilidad","category-inmunologia","category-microbiologia","tag-carmen-diaz-donado","tag-davila-gonzalez-jose-ignacio","tag-felix-lorente-toledano","tag-manuela-cuevas-agustin","tag-melchor-alvarez-de-mon-soto","tag-santiago-quirce-gancedo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37281","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37281"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37281\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}