{"id":37321,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-estructura-y-reactividad-de-pirrolodiazinas\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"sintesis-estructura-y-reactividad-de-pirrolodiazinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-estructura-y-reactividad-de-pirrolodiazinas\/","title":{"rendered":"Sintesis, estructura y reactividad de pirrolodiazinas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Minguez Ortega Jos\u00e9 Miguel <\/strong><\/h2>\n<p>1. Se han desarrollado rutas sint\u00e9ticas alternativas para los heterociclos de 3,4-dihi- dropirrolo (1,2-a)pirazina(1), pirrolo(1,2-a) pirazina (2) y pirrolo(1,2-c)pirimidina(3) que mejoran el rendimiento de los m\u00e9todos sint\u00e9ticos que para ellos han sido descritos en la literatura. Actualmente se est\u00e1n desarrollando nuevas rutas para la pirrolo(1,2-b) piridazina y la pirrolo(1,2-a)pirimidina.  2. La pirrolo(1,2-a)pirazina(2) se ha preparado en dos pasos sint\u00e9ticos a partir del pirrol, utilizando como intermedio el sistema de 3,4-dihidropirrolo(1,2-a)pirazina. Por otra parte, la ruta sint\u00e9tica dise\u00f1ada para la pirrolo(1,2-c)pirimidina est\u00e1 basada en la condensaci\u00f3n de 2-pirrolcarboxaldeh\u00eddo con tosmic, y emplea como intermedios 3-tosil- pirrolo(1,2-c)pirimidinas.  3. Para todos los is\u00f3meros de pirrolodiazina y para la 3,4-dihidropirrolo(1,2-a)pirazina se ha realizado un estudio estructural por medio de c\u00e1lculos ab initio que ha proporcionado informaci\u00f3n acerca de los par\u00e1metros moleculares geom\u00e9tricos, termodin\u00e1micos y electr\u00f3nicos de estos sistemas.  4. Se ha estudiado la reactividad b\u00e1sica de los sistemas 1 &#8211; 3. Los agentes electr\u00f3filos se dirigen preferentemente a la posici\u00f3n alfa del nitr\u00f3geno pirr\u00f3lico, mientras que las reacciones de metalaci\u00f3n tienen lugar en la posici\u00f3n c-4 en la pirrolo(1,2-a)pirazina y en c-1 en la pirrolo(1,2-c)pirimidina.  5. Estos tres sistemas han sido alquilados y aminados en el nitr\u00f3geno az\u00ednico para rendir con buenos rendimientos las correspondientes sales cuaternarias que han sido sometidas a reacciones de cicloadici\u00f3n 1,3-dipolar en condiciones bif\u00e1sicas con diversos dipolar\u00f3filos.  6. El estudio de la regioqu\u00edmica de las cicloadiciones 1,3-dipolares, tanto con acetilenos como con olefinas no sim\u00e9tricas, demuestra que las reacciones han sido totalmente regioselectivas, con el sustituyente electroatractor del dipolar\u00f3filo en la posici\u00f3n c-1 del cicloaducto re<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis, estructura y reactividad de pirrolodiazinas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis, estructura y reactividad de pirrolodiazinas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Minguez Ortega Jos\u00e9 Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>builla G\u00f3mez \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Enrique Galvez Ruano <\/li>\n<li>Jos\u00e9 Cristobal L\u00f3pez P\u00e9rez (vocal)<\/li>\n<li>Mar\u00eda  Ermitas Alcalde Pais (vocal)<\/li>\n<li>Victor Sipido (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Minguez Ortega Jos\u00e9 Miguel 1. Se han desarrollado rutas sint\u00e9ticas alternativas para los heterociclos de 3,4-dihi- dropirrolo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,1412,17,416],"tags":[3100,31680,24741,25489,97975,97976],"class_list":["post-37321","post","type-post","status-publish","format-standard","hentry","category-alcala","category-compuestos-heterociclicos","category-quimica","category-quimica-organica","tag-builla-gomez-alvarez","tag-enrique-galvez-ruano","tag-jose-cristobal-lopez-perez","tag-maria-ermitas-alcalde-pais","tag-minguez-ortega-jose-miguel","tag-victor-sipido"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37321"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37321\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}