{"id":37347,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sistemas-de-transduccion-de-senales-y-niveles-de-somatostatina-en-el-pancreas-de-la-rata-en-condiciones-fisiologicas-y-patologicas\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"sistemas-de-transduccion-de-senales-y-niveles-de-somatostatina-en-el-pancreas-de-la-rata-en-condiciones-fisiologicas-y-patologicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sistemas-de-transduccion-de-senales-y-niveles-de-somatostatina-en-el-pancreas-de-la-rata-en-condiciones-fisiologicas-y-patologicas\/","title":{"rendered":"Sistemas de transduccion de se\u00f1ales y niveles de somatostatina en el pancreas de la rata en condiciones fisiologicas y patologicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eulalia Rodriguez Martin <\/strong><\/h2>\n<p>La somatostatina (ss) es un neurotransmisor\/neuromodulador ampliamente distribuido en el organismo de mam\u00edferos. Sus acciones biol\u00f3gicas est\u00e1n mediadas por su uni\u00f3n a receptores espec\u00edficos de alta afinidad localizados en la membrana de los \u00f3rganos diana.  estos receptores se encuentran acoplados a m\u00faltiples sistemas efectores y su activaci\u00f3n conlleva la modulaci\u00f3n de diferentes v\u00edas de transducci\u00f3n de se\u00f1ales. En el p\u00e1ncreas exocrino de la rata, el \u00f3xido n\u00edtrico act\u00faa regulando el sistema receptor-efector de la ss. Este efecto se demuestra por la acci\u00f3n de la l-arginina, sustrato de la enzima \u00f3xido n\u00edtrico sintetasa, sobre dicho sistema. El sistema somatostatin\u00e9rgico tambi\u00e9n se encuentra implicado en la regulaci\u00f3n negativa de la proliferaci\u00f3n pancre\u00e1tica que tiene lugar en condiciones fisiol\u00f3gicas al final de la lactaci\u00f3n y el destete y como resultado de un proceso adaptativo tras una gastrectom\u00eda total. En este \u00faltimo caso, los cambios provocados por la gastrectom\u00eda sobre el sistema somatostatin\u00e9rgico pancre\u00e1tico implican la activaci\u00f3n del receptor de colecistoquinina\/gastrina. Respecto a las condiciones patol\u00f3gicas, la pancreatitis aguda inducida experimentalmente por oclusi\u00f3n del conducto biliar com\u00fan y el tratamiento cr\u00f3nico con reserpina, un modelo experimental de fibrosis qu\u00edstica, provocan una alteraci\u00f3n del sistema receptor-efector de la ss en el p\u00e1ncreas de la rata. Por otra parte, la prote\u00edna quinasa c (pkc), implicada en procesos de proliferaci\u00f3n celular, y concretamente la isoforma delta de la pkc, parece jugar un papel importante en los cambios fisiol\u00f3gicos del p\u00e1ncreas exocrino que tienen lugar durante la lactaci\u00f3n y tras el detete. Asimismo, las isoformas alfa-, -delta y -epsilon la pkc presentan cambios relacionados con el sexo en su translocaci\u00f3n a nivel de los acinos pancre\u00e1ticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sistemas de transduccion de se\u00f1ales y niveles de somatostatina en el pancreas de la rata en condiciones fisiologicas y patologicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sistemas de transduccion de se\u00f1ales y niveles de somatostatina en el pancreas de la rata en condiciones fisiologicas y patologicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eulalia Rodriguez Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Arilla Ferreiro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel P\u00e9rez Albarsanz <\/li>\n<li>Antonio G\u00f3mez Pan (vocal)<\/li>\n<li>Eladio Montoya Melgar (vocal)<\/li>\n<li>Susana Lopez Sa\u00f1udo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eulalia Rodriguez Martin La somatostatina (ss) es un neurotransmisor\/neuromodulador ampliamente distribuido en el organismo de mam\u00edferos. Sus [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,160,258,17],"tags":[14365,10770,1690,98016,23384,17610],"class_list":["post-37347","post","type-post","status-publish","format-standard","hentry","category-alcala","category-bioquimica","category-hormonas","category-quimica","tag-antonio-gomez-pan","tag-eduardo-arilla-ferreiro","tag-eladio-montoya-melgar","tag-eulalia-rodriguez-martin","tag-miguel-angel-perez-albarsanz","tag-susana-lopez-sanudo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37347"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37347\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37347"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37347"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}