{"id":37358,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-expresion-de-proteina-p53-en-el-adenocarcinoma-colorrectal\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"valor-pronostico-de-la-expresion-de-proteina-p53-en-el-adenocarcinoma-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-de-la-expresion-de-proteina-p53-en-el-adenocarcinoma-colorrectal\/","title":{"rendered":"Valor pronostico de la expresion de proteina p53 en el adenocarcinoma colorrectal."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Tobaruela De Blas Estela <\/strong><\/h2>\n<p>Introduccion: la mutaci\u00f3n en el gen supresor p53 es un evento tard\u00edo en la carcinog\u00e9nesis colorrectal y se ha relacionado con una mayor agresividad tumoral y con un peor pron\u00f3stico. La prote\u00edna codificada por el gen mutado tiene una conformaci\u00f3n alterada y se acumula en las c\u00e9lulas por lo que puede ser detectada por inmunohistoqu\u00edmica en el tejido tumoral y tambi\u00e9n se ha descrito que puede estar relacionada con un peor pron\u00f3stico.  objetivo: analizar el valor pron\u00f3stico de la expresi\u00f3n de prote\u00edna p53 para pacientes con adenocarcinoma colorrectal.  pacientes y metodos: el estudio se realiz\u00f3 con los datos recogidos prospectivamente de una serie clinica de 141 pacientes a los que se realiz\u00f3 la resecci\u00f3n quir\u00fargica de un adenocarcinoma colorrectal entre 6\/1989 y 12\/1995.  se estudi\u00f3 la expresi\u00f3n de prote\u00edna p53 por inmunohistoqu\u00edmica con el anticuerpo policlonal cm1 en tejido tumoral. Otras variables cl\u00ednico-patol\u00f3gicas estudiadas fueron: edad, sexo, localizaci\u00f3n tumoral, tipo de intervenci\u00f3n, cea s\u00e9rico preoperatorio, met\u00e1stasis a distancia, tratamiento radioter\u00e1pico preoperatorio, tipo histol\u00f3gico, invansi\u00f3n pariental, presencia y numero de met\u00e1stasis ganglionares, grado histologico, tipo de borde tumoral, infiltrado linfoplasmocitario, invasi\u00f3n perineural, infiltraci\u00f3n vascular, grado de ploid\u00eda, expresi\u00f3n de pcna y estadio histopatol\u00f3gico (astler-coller y jass).  se analiz\u00f3 la relaci\u00f3n entre las categor\u00edas establecidas para estas variables y la presencia o no de sobreexpresi\u00f3n de esta prote\u00edna, as\u00ed como su influencia en el pron\u00f3stico de recurrencia y de supervivencia de estas variables.  resultados:  el 52,5% de los adenocarcinomas colorrectales presentaban sobreexpresi\u00f3n nuclear de prote\u00edna p53. La sobreexpresi\u00f3n de prote\u00edna p53 se relacion\u00f3 con la presencia de un cea s\u00e9rico preoperatorio elevado (p=0,006), con tumores asociados a met\u00e1stasis a distancia en el momento del<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pronostico de la expresion de proteina p53 en el adenocarcinoma colorrectal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pronostico de la expresion de proteina p53 en el adenocarcinoma colorrectal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Tobaruela De Blas Estela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Diaz Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Garcia  Sancho Martin <\/li>\n<li>Javier Cerdan Miguel (vocal)<\/li>\n<li>Luis Alberto Gonz\u00e1lez Guijarro (vocal)<\/li>\n<li>Antonio Ruiz Villaespina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tobaruela De Blas Estela Introduccion: la mutaci\u00f3n en el gen supresor p53 es un evento tard\u00edo en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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