{"id":37364,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-lipidos-y-metabolismo-del-acido-araquidonico-en-plaquetas-de-pacientes-con-insuficiencia-renal-cronica\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-de-lipidos-y-metabolismo-del-acido-araquidonico-en-plaquetas-de-pacientes-con-insuficiencia-renal-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-lipidos-y-metabolismo-del-acido-araquidonico-en-plaquetas-de-pacientes-con-insuficiencia-renal-cronica\/","title":{"rendered":"Estudio de lipidos y metabolismo del acido araquidonico en plaquetas de pacientes con insuficiencia renal cronica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vecino Morales Ana M. <\/strong><\/h2>\n<p>Los pacientes con insuficiencia renal cr\u00f3nica (irc) desarrollan un defecto plaquetario caracterizado \u00abin vitro\u00bb por una disminuci\u00f3n en la agregaci\u00f3n. Esta funci\u00f3n est\u00e1 regulada por la acci\u00f3n de fosfolipasas que generan \u00e1cido araquid\u00f3nico libre (aa), el cual es posteriormente metabolizado a hidroxi\u00e1cidos (hht, hete) y tromboxano b2 (txb2).  plaquetas lavadas se marcaron con c-14-\u00e1cido araquid\u00f3nico (c-14-aa) y se activaron con trombina (5u\/ml) o ionn\u00f3foro (4ugr\/ml). Los l\u00edpidos se separaron por tlc y se identificaron por autoradiograf\u00eda. La incororaci\u00f3n y distribuci\u00f3n de c-14-aa en los fosfol\u00edpidos plaquetarios fue normal. La generaci\u00f3n de \u00e1cido fosfat\u00eddico fue similar en pacientes y controles (4.1+-0.6% vs 3.1+-1.5% de radioactividad total), as\u00ed como la radioactividad liberada de los fosfol\u00edpidos (15.3+-11% vs10.5+-5.0%). La activaci\u00f3n con ion\u00f3foro liber\u00f3 m\u00e1s radioactividad en las plaquetas de los pacientes (18.6+-5.2% vs11.3+-1.6%, p&lt;0.01). En este experimento, la generaci\u00f3n de txb2 y hht fue normal, pero se detect\u00f3 un incremento en la formaci\u00f3n de hete, producto derivado de la lipoxigenasa (12.9+-4.6% vs 7.0+-1.3%, p&lt;0.01). Cuando se activaron las plaquetas con c-14-aa se encontr\u00f3 un metabolismo preferente a hete en los pacientes (78.9+-8.4 vs 63.2+-8.9%, p&lt;0.01) y un defecto en la formaci\u00f3n de txb2 (6.8+-4.0% vs 14.1+-7.4, p&lt;0.05) y hht (12.6+-4.7 vs 22.4+-4.3, p&lt;0.01). Ambas alteraciones podr\u00edan justificar una disfunci\u00f3n plaquetaria en la irc.  se encontr\u00f3 un aumento de los fosfol\u00edpidos en el plasma de los pacientes a expensas de la fosfatidilcolina. Se descart\u00f3 la participaci\u00f3n de la lisofosfatidilcolina en la alteraci\u00f3n de las plaquetas.  se detect\u00f3 una disminuci\u00f3n en la cantidad de fosfol\u00edpidos plaquetarios y un aumento en la relacion colesterol\/fosfol\u00edpidos.  en resumen: las actividades de las enzimas de las que depende la incorporaci\u00f3n de aa a a los fosfol\u00edpido<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de lipidos y metabolismo del acido araquidonico en plaquetas de pacientes con insuficiencia renal cronica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de lipidos y metabolismo del acido araquidonico en plaquetas de pacientes con insuficiencia renal cronica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vecino Morales Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Herrera Castillon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Eduardo Arilla Ferreiro <\/li>\n<li>Luis Escribano Mora (vocal)<\/li>\n<li>Matilde Salinas Aracil (vocal)<\/li>\n<li>Pedro Gonzalez Porque (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vecino Morales Ana M. Los pacientes con insuficiencia renal cr\u00f3nica (irc) desarrollan un defecto plaquetario caracterizado \u00abin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,9,218,139,179],"tags":[10770,96,41390,17565,46561,98042],"class_list":["post-37364","post","type-post","status-publish","format-standard","hentry","category-alcala","category-ciencias-medicas","category-hematologia","category-medicina-interna","category-nefrologia","tag-eduardo-arilla-ferreiro","tag-emilio-herrera-castillon","tag-luis-escribano-mora","tag-matilde-salinas-aracil","tag-pedro-gonzalez-porque","tag-vecino-morales-ana-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37364"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37364\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}