{"id":37418,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-hemofiltracion-sobre-un-modelo-de-coagulacion-intravascular-diseminada-cid-inducida-por-endotoxina-en-conejos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efectos-de-la-hemofiltracion-sobre-un-modelo-de-coagulacion-intravascular-diseminada-cid-inducida-por-endotoxina-en-conejos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-la-hemofiltracion-sobre-un-modelo-de-coagulacion-intravascular-diseminada-cid-inducida-por-endotoxina-en-conejos\/","title":{"rendered":"Efectos de la hemofiltracion sobre un modelo de coagulacion intravascular diseminada (cid) inducida por endotoxina en conejos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Buades Fuster Juan  Andres <\/strong><\/h2>\n<p>La coagulaci\u00f3n intravascular diseminada es un s\u00edndrome caracterizado por una profunda alteraci\u00f3n de la hemostasia. Su etiolog\u00eda es m\u00faltiple, si bien la sepsis por bacterias gramnegativas representa una de las causas m\u00e1s frecuentes e importantes. La endotoxina de estos microorganismos, bien directamente o a trav\u00e9s de los monocitos y las c\u00e9lulas endoteliales que liberan citoquinas (tnf, il-1, il-6, etc), activa la coagulaci\u00f3n por la v\u00eda del factor tisular, por lo que se genera gran cantidad de trombina en la sangre circulante que va a originar el dep\u00f3sito de fibrina en la microcirculaci\u00f3n y fallo multiorg\u00e1nico. Tambi\u00e9n est\u00e1n implicados el consumo de los inhibidores de la coagulaci\u00f3n (antitrombina iii, prote\u00edna c&#8230;) Y la inactivaci\u00f3n de la fibrinolisis (disminuci\u00f3n de t-pa y aumento de pai-1).  se ha evaluado el efecto de la hemofiltraci\u00f3n continua en un modelo experimental de cid en conejos inducido por la infusi\u00f3n cont\u00ednua de endotoxina de e.Coli(100 g\/kg\/h). Se han utilizado 5 grupos de 10 conejos cada uno. El grupo a recibi\u00f3 suero salino durante 6 horas. El grupo b recibi\u00f3 endotoxina y suero salino. El grupo c recibi\u00f3 hemofiltraci\u00f3n y heparina como anticoagulante (200 ui\/kg inicial con infusi\u00f3n posterior de 20 ui\/kg\/h).  el grupo d recibi\u00f3 endotoxina, hemofiltraci\u00f3n y heparina, el grupo e recibi\u00f3 endotoxina y heparina. Las muestras de sangre se extrajeron antes de la endotoxina, a la 2 y a las 6 horas para determinar plaquetas, fibrin\u00f3geno, factor xii, at iii, prote\u00edna c, plasmin\u00f3geno, t-pa y pai.  la mortalidad y los dep\u00f3sitos renales de fibrina se evaluaron 24 horas despu\u00e9s de concluida la infusi\u00f3n, esta \u00faltima mediante una escala (de 0 a 4) previamente descrita (g\u00f3mez y col. Thromb haemostas 1989; 62: 694).  la cid estaba claramente presente en el grupo b como lo demuestra el descenso de plaquetas, fibrin\u00f3geno, factor xii, at iii y prote\u00edna c. Tambi\u00e9n se objetiv\u00f3 una reducci\u00f3n sig<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la hemofiltracion sobre un modelo de coagulacion intravascular diseminada (cid) inducida por endotoxina en conejos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la hemofiltracion sobre un modelo de coagulacion intravascular diseminada (cid) inducida por endotoxina en conejos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Buades Fuster Juan  Andres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Andres Purroy Unanua<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas M. Prieto Valtue\u00f1a <\/li>\n<li>Fernando Valderrabano Quintana (vocal)<\/li>\n<li>Joaquin Ortu\u00f1o Mirete (vocal)<\/li>\n<li>Francisco Carrascosa Moreno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Buades Fuster Juan Andres La coagulaci\u00f3n intravascular diseminada es un s\u00edndrome caracterizado por una profunda alteraci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,218,139,17749,179],"tags":[18360,98125,7024,17873,15059,14928],"class_list":["post-37418","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-hematologia","category-medicina-interna","category-navarra","category-nefrologia","tag-andres-purroy-unanua","tag-buades-fuster-juan-andres","tag-fernando-valderrabano-quintana","tag-francisco-carrascosa-moreno","tag-jesus-m-prieto-valtuena","tag-joaquin-ortuno-mirete"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37418"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37418\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}