{"id":37445,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/lesiones-endometriales-inducidas-por-tamoxifeno-estudio-experimental-en-ratas\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"lesiones-endometriales-inducidas-por-tamoxifeno-estudio-experimental-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/lesiones-endometriales-inducidas-por-tamoxifeno-estudio-experimental-en-ratas\/","title":{"rendered":"Lesiones endometriales inducidas por tamoxifeno: estudio experimental en ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Enguita M. Pilar <\/strong><\/h2>\n<p>Objetivos: comprobar si el tamoxifeno es capaz de inducir alteraciones histol\u00f3gicas en el endometrio propias de un efecto agonista o antagonista estrog\u00e9nico, y si \u00e9stas presentan car\u00e1cter neopl\u00e1sico. Valorar si la acci\u00f3n de un cancer\u00edgeno se modifica por el tamoxifeno y viceversa.  material y m\u00e9todos: 117 ratas castradas distribuidas en 4 grupos: i-control, ii-tamoxifeno, iii-cancer\u00edgeno, iv-tamoxifeno y cancer\u00edgeno. El tamoxifeno fu\u00e9 administrado v\u00eda oral (5 mg\/kg\/d\u00eda) y el metilcolantreno intrauterinamente seg\u00fan el m\u00e9todo del hilo de algod\u00f3n.  resultados: grupo i: \u00fateros y endometrios atr\u00f3ficos.  grupo ii: \u00fateros congestivos con endometrio atr\u00f3fico y apoptosis. Grupo iii: hiperplasia endometrial con atipias, metaplasia col\u00f3nica y escamosa, inflamaci\u00f3n aguda y cr\u00f3nica, y un sarcoma endometrial. Grupo iv:  metaplasia escamosa queratinizante, inflamaci\u00f3n aguda y cr\u00f3nica, y un sarcoma endometrial. El tamoxifeno redujo el incremento de peso corporal, efecto potenciado en grupo iv. Conclusiones: el tamoxifeno no produce lesiones preneopl\u00e1sicas ni por s\u00ed mismo ni en presencia de un cancer\u00edgeno. El modelo de carcinog\u00e9nesis con metilcolantreno no se reproduce exactamente en la rata:  no produce adenocarcinomas, aunque s\u00ed lesiones preneopl\u00e1sicas y metaplasia col\u00f3nica. Sus efectos son modificados por el tamoxifeno.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Lesiones endometriales inducidas por tamoxifeno: estudio experimental en ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Lesiones endometriales inducidas por tamoxifeno: estudio experimental en ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Enguita M. Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Dominguez Cunchillos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Guillermo L\u00f3pez Garc\u00eda <\/li>\n<li>Eduard Escrich Escriche (vocal)<\/li>\n<li>Miguel Prats Esteve (vocal)<\/li>\n<li>Gregorio Tiberio Lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Enguita M. Pilar Objetivos: comprobar si el tamoxifeno es capaz de inducir alteraciones histol\u00f3gicas en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,135,17749,156,1323],"tags":[13964,32177,98166,28313,9291,13962],"class_list":["post-37445","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-ginecologia","category-navarra","category-patologia","category-patologia-experimental","tag-eduard-escrich-escriche","tag-fernando-dominguez-cunchillos","tag-garcia-enguita-m-pilar","tag-gregorio-tiberio-lopez","tag-guillermo-lopez-garcia","tag-miguel-prats-esteve"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37445"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37445\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}