{"id":37446,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/profilaxis-del-dano-de-isquemia-reperfusion-en-el-by-pass-aortocoronario-con-alopurinol-y-n-acetilcisteina\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"profilaxis-del-dano-de-isquemia-reperfusion-en-el-by-pass-aortocoronario-con-alopurinol-y-n-acetilcisteina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/profilaxis-del-dano-de-isquemia-reperfusion-en-el-by-pass-aortocoronario-con-alopurinol-y-n-acetilcisteina\/","title":{"rendered":"Profilaxis del da\u00f1o de isquemia-reperfusion en el by-pass aortocoronario con alopurinol y n-acetilcisteina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Garcia Fuster <\/strong><\/h2>\n<p>Existe un importante da\u00f1o oxidativo durante la reperfusi\u00f3n card\u00edaca en cirug\u00eda extracorp\u00f3rea y aunque las t\u00e9cnicas actuales de protecci\u00f3n mioc\u00e1rdica pueden ser suficientes para amortiguar la lesi\u00f3n mioc\u00e1rdica durante la isquemia, se realizan estudios para limitar el da\u00f1o por reperfusi\u00f3n. Antioxidantes como el alopurinol y la n-acetilciste\u00edna (nac) pueden ser \u00fatiles. Se ha realizado un estudio prospectivo, randomizado y doble ciego con 60 pacientes sometidos a bypass aortocoronario. Se crearon tres grupos de 20 pacientes seg\u00fan el tratamiento administrado el d\u00eda previo a la intervenci\u00f3n: grupo i:  alopurinol, 300 mg\/8h; grupo ii: nac, 4g\/8h; grupo iii:placebo. Todas las intervenciones fueron realizadas por un mismo cirujano y con un manejo perioperatorio uniforme. Se valor\u00f3 la evoluci\u00f3n cl\u00ednica, cifras de cpk e \u00edndices hemodin\u00e1micos perioperatorios. La evoluci\u00f3n enzim\u00e1tica y hemodin\u00e1mica fu\u00e9 similar, sin diferencias en precarga, postcarga y frecuencia card\u00edaca. Los \u00edndices de funci\u00f3n ventricular fueron tambi\u00e9n similares sin diferencias significativas en el an\u00e1lisis de su evoluci\u00f3n temporal. Pero el empleo de inotr\u00f3picos fu\u00e9 menor en los grupos alopurinol y nac, con dosis medias de dobutamina de 2.11+-0.38, 1.01+-0.21 y 1.27+-0.28  g\/kg\/mi para el placebo, alopurinol y nac respectivamente (p&lt;0.05). El ritmo sinusal potisquemia fu\u00e9 menos frecuente en el grupo placebo, el cual present\u00f3 una mayor incidencia de arritmias postoperatorias (9, 3 y 4 pacientes, p&lt;0.05).  el pretratamiento con alopurinol o nac en el bypass aortocoronario preserva el ritmo sinusal tras el desclampaje a\u00f3rtico y permite reducir la incidencia de arritmias postoperatorias y el empleo de inotr\u00f3picos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Profilaxis del da\u00f1o de isquemia-reperfusion en el by-pass aortocoronario con alopurinol y n-acetilcisteina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Profilaxis del da\u00f1o de isquemia-reperfusion en el by-pass aortocoronario con alopurinol y n-acetilcisteina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Garcia Fuster <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Diego Mart\u00ednez Caro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas M. Prieto Valtue\u00f1a <\/li>\n<li>Fernando Del Pozo (vocal)<\/li>\n<li>Jes\u00fas Herreros Gonzalez (vocal)<\/li>\n<li>Alejandro Martin Trenor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Garcia Fuster Existe un importante da\u00f1o oxidativo durante la reperfusi\u00f3n card\u00edaca en cirug\u00eda extracorp\u00f3rea y aunque [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,2189,17749],"tags":[89399,18298,98168,17967,15059,98167],"class_list":["post-37446","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-cardiaca","category-navarra","tag-alejandro-martin-trenor","tag-diego-Martinez-caro","tag-fernando-del-pozo","tag-jesus-herreros-gonzalez","tag-jesus-m-prieto-valtuena","tag-rafael-garcia-fuster"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37446","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37446"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37446\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37446"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37446"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37446"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}