{"id":37475,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-y-mecanismos-de-produccion-de-las-lesiones-tras-injuria-arterial-en-un-modelo-de-cerdo-hipercolesterolemico\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"caracterizacion-y-mecanismos-de-produccion-de-las-lesiones-tras-injuria-arterial-en-un-modelo-de-cerdo-hipercolesterolemico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-y-mecanismos-de-produccion-de-las-lesiones-tras-injuria-arterial-en-un-modelo-de-cerdo-hipercolesterolemico\/","title":{"rendered":"Caracterizacion y mecanismos de produccion de las lesiones tras injuria arterial en un modelo de cerdo hipercolesterolemico."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martinez Monzonis M. Amparo <\/strong><\/h2>\n<p>Introducci\u00f3n: la reestenosis constituye la principal limitaci\u00f3n de la angioplastia. El objetivo de este trabajo fue evaluar en un modelo animal de cerdo miniatura hipercolesterol\u00e9mico el remodelado arterial y la proliferaci\u00f3n celular tras la angioplasia en tres territorios arteriales diferentes.  material y m\u00e9todo: 46 cerdos miniatura goettingen siguieron una dieta estandar (nc=19) o hipercolesterol\u00e9mica (hc=27) durante 4 semanas. Tras este periodo de tiempo con la dieta se realiz\u00f3 sobredistensi\u00f3n con bal\u00f3n de angioplastia en las arterias il\u00edaca externa, interna y coronaria izquierda. Los animales fueron sacrificados 8 semanas despues, tras la realizaci\u00f3n de una nueva angiograf\u00eda. Los segmentos lesionados y los sanos fueron procesados para estudio histol\u00f3gico e inmunohistoqu\u00edmico. En cada uno de ellos se determin\u00f3 el \u00e1rea de secci\u00f3n, el \u00e1rea de la luz arterial, \u00e1rea de neo\u00edntima, \u00e1rea rodeada por la l\u00e1mina el\u00e1stica externa (lee), porcentaje de estenosis (%e), n\u00famero de n\u00facleos (na) y actividad mit\u00f3tica.  resultados: en todos los segmentos lesionados se objetiv\u00f3 la existencia de estenosis angiogr\u00e1fica, no existiendo diferencias en el grado de estenosis entre los diferentes tipos de arterias. En los segmentos lesionados se comprob\u00f3 la existencia de una neo\u00edntima exc\u00e9ntrica con l\u00e1mina el\u00e1stica interna \u00edntegra. No se encontraron diferencias en el %e, actividad mit\u00f3tica y lee. En los segmentos lesionados se comprob\u00f3 un aumento de la expresi\u00f3n de pcna en relaci\u00f3n con la zona sana adyacente a la lesi\u00f3n. No existieron diferencias significativas en los par\u00e1metros estudiados entre los animales nc e hc.  conclusiones: en el modelo propuesto, la reestenosis postangioplastia puede ser consecuencia de un aumento del \u00e1rea neointimal secundaria a la proliferaci\u00f3n celular, sin existir remodelado significativo. Ni los niveles de colesterol ni el tipo de arteria influy\u00f3 en la respuesta histol\u00f3gica a la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion y mecanismos de produccion de las lesiones tras injuria arterial en un modelo de cerdo hipercolesterolemico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion y mecanismos de produccion de las lesiones tras injuria arterial en un modelo de cerdo hipercolesterolemico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martinez Monzonis M. Amparo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Diego Mart\u00ednez Caro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Arturo Cortina Llosa <\/li>\n<li>Eduardo Alegria Ezquerra (vocal)<\/li>\n<li>Francisco Javier Chorro Gasc\u00f3 (vocal)<\/li>\n<li>Joaqu\u00edn Barba Cosials (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martinez Monzonis M. Amparo Introducci\u00f3n: la reestenosis constituye la principal limitaci\u00f3n de la angioplastia. El objetivo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[932,9,139,17749,156,1601],"tags":[2975,18298,18215,11531,18054,98210],"class_list":["post-37475","post","type-post","status-publish","format-standard","hentry","category-cardiologia","category-ciencias-medicas","category-medicina-interna","category-navarra","category-patologia","category-patologia-cardiovascular","tag-arturo-cortina-llosa","tag-diego-Martinez-caro","tag-eduardo-alegria-ezquerra","tag-francisco-javier-chorro-gasco","tag-joaquin-barba-cosials","tag-Martinez-monzonis-m-amparo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37475"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37475\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}