{"id":37476,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inhibicion-selectiva-de-fosfodiesterasas-en-el-diseno-de-farmacos-vasodilatadores\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"inhibicion-selectiva-de-fosfodiesterasas-en-el-diseno-de-farmacos-vasodilatadores","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/inhibicion-selectiva-de-fosfodiesterasas-en-el-diseno-de-farmacos-vasodilatadores\/","title":{"rendered":"Inhibicion selectiva de fosfodiesterasas en el dise\u00f1o de farmacos vasodilatadores."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Mercapide Muguerza <\/strong><\/h2>\n<p>La acci\u00f3n vasorrelajante de muchos reguladores del tono muscular de los vasos sangu\u00edneos, tiene lugar a trav\u00e9s de cambios en la concentraci\u00f3n de gmpc en este tejido, como por ejemplo los nitrocompuestos muy empleados en el tratamiento de enfermedades cardiovasculares. La vasodilataci\u00f3n inducida por gmpc termina con su hidr\u00f3lisis por fosfodiesterasas. El objetivo de este trabajo ha sido determinar si la inhibici\u00f3n selectiva de fosfodiesterasas de gmpc puede potenciar la cantidad de gmpc obtenida tras estimulaci\u00f3n con nitrocompuestos. Para ello se aislaron las fosfodiesterasas de aorta de cerdo encontr\u00e1ndose que la fosfodiesterasa estimulable con calcio-calmodulina (pde i) y la fosfodiesterasa espec\u00edfica de gmpc (pde v) son fuertemente expresadas en este tejido. La degradaci\u00f3n de gmpc tiene lugar activamente cuando la concentraci\u00f3n intracelular de gmpc aumenta en respuesta a agentes que estimulan su s\u00edntesis, como el nitroprusiato s\u00f3dico (nps) o el factor natriur\u00e9tico atrial (ena). Nuestros resultados sugieren que tanto pde i como pde v hidrolizan el gmpc sintetizado tras la activaci\u00f3n con ambos agentes, y la inhibici\u00f3n selectiva de cualquiera de ellas es necesaria pero no suficiente para potenciar la respuesta.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inhibicion selectiva de fosfodiesterasas en el dise\u00f1o de farmacos vasodilatadores.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inhibicion selectiva de fosfodiesterasas en el dise\u00f1o de farmacos vasodilatadores. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Mercapide Muguerza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jos\u00e9 Mart\u00ednez Irujo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Santiago Calvo <\/li>\n<li>Aida Marino Sanchez (vocal)<\/li>\n<li> Gomez Moreno Galera Carlos (vocal)<\/li>\n<li>Mar\u00eda  Jes\u00fas Lopez Zabalza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Mercapide Muguerza La acci\u00f3n vasorrelajante de muchos reguladores del tono muscular de los vasos sangu\u00edneos, tiene [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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