{"id":37482,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-del-estado-oxidativo-de-vitreo-y-retina-en-un-modelo-porcino-de-hipercolesterolemia\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"analisis-del-estado-oxidativo-de-vitreo-y-retina-en-un-modelo-porcino-de-hipercolesterolemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/analisis-del-estado-oxidativo-de-vitreo-y-retina-en-un-modelo-porcino-de-hipercolesterolemia\/","title":{"rendered":"Analisis del estado oxidativo de vitreo y retina en un modelo porcino de hipercolesterolemia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Moya Molina <\/strong><\/h2>\n<p>Aunque la hipercolesterolemia es un factor de riesgo importante en las enfermedades cardiovasculares, hasta la fecha no se ha demostrado una relaci\u00f3n directa entre la hipercolesterolemia y patolog\u00edas oculares. Este estudio intenta establecer si las dietas ricas en colesterol, en un modelo animal porcino, pueden inducir cambios en el stress oxidativo ocular, y si \u00e9stos pueden ser revertidos por los antioxidantes.  el grupo control (n=21 cerdos) se aliment\u00f3 con dieta porcina estandar, el grupo hipercolesterol\u00e9mico (n=14) recibi\u00f3 una dieta complementada con colesterol, sebo y extracto de bilis. El grupo antioxidante (n=24) recibi\u00f3 dieta hipercolesterol\u00e9mica, con un suplemento diario de vitamina c(1 g) y vitamina e(1000 iu) durante el \u00faltimo mes.  los productos de peroxidaci\u00f3n lip\u00eddica se midieron en v\u00edtreo y retina con el ensayo \u00e1cido de sustancias reactivas al \u00e1cido tiobarbit\u00farico (tbars). Los radicales libres en el epitelio pigmentario retiniano se determinaron por la reacci\u00f3n con la lucigenina y recuento de fotones. Los nitritos y los nitratos se determinaron en v\u00edtreo y retina con un analizador de \u00f3xido n\u00edtrico.  la peroxidaci\u00f3n lip\u00eddica retiniana en el grupo hipercolesterol\u00e9mico (22+-3,82 mim mda\/mg prot) fu\u00e9 significativamente m\u00e1s alta que el control (5,41+-1,35 mim mda\/mg prot, p&lt;0,0001) y el grupo tratado con antioxidantes (9,49+-2,29 mim mda\/mg prot, p&lt;0,01). La producci\u00f3n de radicales libres fu\u00e9 significativamente m\u00e1s alta en el grupo hipercolesterol\u00e9mico (127,4+-25,47 cpm\/mg), que en el control (64,8+-4,40 cpm\/mg,p&lt;0,05) y que en el grupo tratado con antioxidantes (47,60+-5,80 cpm\/mg, p&lt;0,0001). La producci\u00f3n de \u00f3xido n\u00edtrico en las retinas hipercolesterol\u00e9micas (16,53+-4,58 mim) fu\u00e9 significativamente m\u00e1s alta que en las del grupo control (7,31+-1,32 mim, p&lt;0,05).  las dietas ricas en colesterol inducen stress oxidativo en la retina y el v\u00edtreo. Este efecto que podr\u00eda<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis del estado oxidativo de vitreo y retina en un modelo porcino de hipercolesterolemia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis del estado oxidativo de vitreo y retina en un modelo porcino de hipercolesterolemia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Moya Molina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Garc\u00eda Layana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Pastor Jimeno <\/li>\n<li>Oscar Beloqui Ruiz (vocal)<\/li>\n<li>Diego Mart\u00ednez Caro (vocal)<\/li>\n<li>Jos\u00e9 Javier Araiz Iribarren (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Moya Molina Aunque la hipercolesterolemia es un factor de riesgo importante en las enfermedades cardiovasculares, hasta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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