{"id":37595,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-2-sulfenamoil-piridincarboxilatos-de-etilo-y-derivados-como-fitorreguladores-y-antineoplasicos-diseno-sintesis-y-optimizacion\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"nuevos-2-sulfenamoil-piridincarboxilatos-de-etilo-y-derivados-como-fitorreguladores-y-antineoplasicos-diseno-sintesis-y-optimizacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/nuevos-2-sulfenamoil-piridincarboxilatos-de-etilo-y-derivados-como-fitorreguladores-y-antineoplasicos-diseno-sintesis-y-optimizacion\/","title":{"rendered":"Nuevos 2-sulfenamoil-piridincarboxilatos de etilo y derivados como fitorreguladores y antineoplasicos; dise\u00f1o, sintesis y optimizacion."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ma\u00f1u Noain M. Angeles <\/strong><\/h2>\n<p>En este trabajo se analizan los m\u00e9todos sint\u00e9ticos y se exploran las posibilidades de aplicaci\u00f3n en los campos agron\u00f3mico y farmace\u00fatico de nuevos productos derivados de las 2-piridinsulfenilureas, sus an\u00e1logos c\u00edclicos isotiazolo (5,4-b)piridina y sus s-\u00f3xidos. se ha demostrado que grupos fuertemente atractores de electrones en la posici\u00f3n 5 del anillo de piridina, desestabilizan los compuestos anteriores. La actividad fitorreguladora se ha determinado utilizando el biotest de crecimiento radicular en ma\u00edz. Los estudios qsar revelan que la hidrofobicidad del sustituyente en 5, el estado de oxidaci\u00f3n del azufre y los sustituyentes de la primidina son determinantes en la actividad fitorreguladora. Los derivados 5-h y 5-ch3 de 2-(n-((j,6-dimetoxi-2-pirimidinil) carbamoil)sulfamoil)-3-piridincarboxilato de etilo fueron los m\u00e1s activos. se ha determinado la actividad antitumoral in vitro sobre las leas celulares ht-29 (c.Colon) y ccfr-cem(leucemia). Varios derivados del n\u00facleo isotiazolo 5,4-b piridina presentan gl50 0,5-2.0 e-6m en ambas l\u00edneas. Los an\u00e1lisis qsar indican que la actividad antineopl\u00e1sica se desencadena por medio de una interacci\u00f3n orbit\u00e1lica, para las estructuras c\u00edclicas de isotiazolo (5,4-b)piridina y por medio de interacciones espec\u00edficas de los grupos so2 y meo para las diarisulfonilureas..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos 2-sulfenamoil-piridincarboxilatos de etilo y derivados como fitorreguladores y antineoplasicos; dise\u00f1o, sintesis y optimizacion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos 2-sulfenamoil-piridincarboxilatos de etilo y derivados como fitorreguladores y antineoplasicos; dise\u00f1o, sintesis y optimizacion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ma\u00f1u Noain M. Angeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 P\u00fablica de navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Gonzalez Guerrero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Gotor <\/li>\n<li>cristina Minguillon llombart (vocal)<\/li>\n<li>Carlos Cativiela (vocal)<\/li>\n<li>ignacio Encio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ma\u00f1u Noain M. Angeles En este trabajo se analizan los m\u00e9todos sint\u00e9ticos y se exploran las posibilidades [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,17670,1903,18529,17,1769,457],"tags":[13432,96270,41062,98374,98373,96944],"class_list":["post-37595","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-diseno-sintesis-y-estudio-de-nuevos-farmacos","category-herbicidas","category-publica-de-navarra","category-quimica","category-quimica-agricola","category-quimica-farmaceutica","tag-alberto-gonzalez-guerrero","tag-carlos-cativiela","tag-cristina-minguillon-llombart","tag-ignacio-encio","tag-manu-noain-m-angeles","tag-vicente-gotor"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37595"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37595\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}