{"id":37740,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-inhibidor-de-carboxipeptidasa-de-patata-pci-un-antagonista-del-egf-con-actividad-antiumoral\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"el-inhibidor-de-carboxipeptidasa-de-patata-pci-un-antagonista-del-egf-con-actividad-antiumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-inhibidor-de-carboxipeptidasa-de-patata-pci-un-antagonista-del-egf-con-actividad-antiumoral\/","title":{"rendered":"El inhibidor de carboxipeptidasa de patata (pci): un antagonista del egf con actividad antiumoral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Blanco Aparicio <\/strong><\/h2>\n<p>En la \u00faltima d\u00e9cada se ha demostrado que una gran variedad de inhibidores de proteasas tienen una fuerte actividad anticarcinog\u00e9nica. Si bien se conocen los posibles procesos de la g\u00e9nesis y desarrollo tumoral en los que interfieren, se desconoce con exactitud el mecanismo por el cual contribuyen a la prevenci\u00f3n del c\u00e1ncer. El presente trabajo constituye una aportaci\u00f3n significativa en dicho contexto. En primer lugar, se ha demostrado que el inhibidor de carboxipeptidasa de patata (pci) tiene un efecto inhibitorio sobre el crecimiento de l\u00edneas celulares tumorales de diferentes or\u00edgenes. Dicho efecto inhibitorio aparece a largo plazo y se mantiene incluso en ausencia del inhibidor. Mediante diferente modelos animales se ha podido comprobar que el pci inhibe el crecimiento de tumores inducidos en ratones at\u00edmicos, as\u00ed como, la aparici\u00f3n de met\u00e1stasis en ratones inoculados con c\u00e9lulas sing\u00e9nicas. A su vez, alarga la supervivencia de ratones transg\u00e9nicos que desarrollan tumores de plexo coroideo e insulinomas.  respecto a su mecanismo celular de acci\u00f3n, mediante citometr\u00eda de flujo se ha detectado que el pci provoca un aumento de c\u00e9lulas apopt\u00f3ticas y cierta parada en go\/g1.  se ha determinado, as\u00edmismo, que el pci es internalizado por las c\u00e9lulas sobre las que tiene efecto sin que sea modificado.  mediante an\u00e1lisis computacional se ha establecido que el pci presenta similaridades estructurales con el factor de crecimiento epid\u00e9rmico (egf). Ello ha llevado a estudiar la interacci\u00f3n del inhibidor con el receptor de egf (egf-r). Se ha demostrado que el pci es un antagonista del egf humano, que compite con dicho factor de crecimiento por la uni\u00f3n a su receptor e inhibe la dimerizaci\u00f3n, actividad quinasa y transfosforilaci\u00f3n del egf-r inducida por el egf, as\u00ed como la proliferaci\u00f3n celular inducida por dicho factor de crecimiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El inhibidor de carboxipeptidasa de patata (pci): un antagonista del egf con actividad antiumoral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El inhibidor de carboxipeptidasa de patata (pci): un antagonista del egf con actividad antiumoral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Blanco Aparicio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Girona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael De Llorens Duran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Lopez Otin <\/li>\n<li>Adela Mazo Sanchez (vocal)<\/li>\n<li>Fernando Vidal Vanaclocha (vocal)<\/li>\n<li>Manuel Antonio Manso Mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Blanco Aparicio En la \u00faltima d\u00e9cada se ha demostrado que una gran variedad de inhibidores de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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