{"id":37847,"date":"2018-03-09T09:37:08","date_gmt":"2018-03-09T09:37:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-funcional-entre-la-adenosina-desaminasa-y-el-receptor-a1-de-adenosina-en-la-superficie-celular\/"},"modified":"2018-03-09T09:37:08","modified_gmt":"2018-03-09T09:37:08","slug":"interaccion-funcional-entre-la-adenosina-desaminasa-y-el-receptor-a1-de-adenosina-en-la-superficie-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/interaccion-funcional-entre-la-adenosina-desaminasa-y-el-receptor-a1-de-adenosina-en-la-superficie-celular\/","title":{"rendered":"Interaccion funcional entre la adenosina desaminasa y el receptor a1 de adenosina en la superficie celular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos A Saura Antolin <\/strong><\/h2>\n<p>La adenosina deaminasa (ada) es una enzima del metabolismo pur\u00ednico que ha sido hallada tanto en el citosol como en la superficie celular. En este estudio se ha demostrado que la ada interacciona con los receptores a1 de adenosina (a1rs) en corteza cerebral de cerdo y en la linea celular ddt1mf-2. A trav\u00e9s de esta interacci\u00f3n la ada aumenta la afinidad del receptor a1 por los ligandos agonistas, permite la aparici\u00f3n del estado de alta afinidad del receptor (receptor-prote\u00edna g) y es necesaria para la correcta transducci\u00f3n de la se\u00f1al del receptor a1.  los mecanismos moleculares involucrados en la desensibilizaci\u00f3n hom\u00f3loga de los a1rs se estudi\u00f3 en c\u00e9lulas ddt1mf-2. La exposici\u00f3n cr\u00f3nica de las c\u00e9lulas con el agonista r- pia produce una r\u00e1pida desensibilizaci\u00f3n funcional, la fosforilaci\u00f3n y la agregaci\u00f3n en la superficie celular de los receptores a1.  la internalizaci\u00f3n de los a1rs hacia compartimentos intracelulares es un proceso lento (horas) y conduce a la down-regulation de \u00e9stos. El antagonista, por el contrario, induce la aparici\u00f3n de nuevos centros de uni\u00f3n en la membrana.  todos los procesos implicados en la desensibilizaci\u00f3n hom\u00f3loga del receptor a1 son acelerados y aumentados por la ada. El agonista induce tambi\u00e9n la internalizaci\u00f3n conjunta de la ada y los a1rs. Estos resultados muestran una regulaci\u00f3n mutua y una v\u00eda de endocitosis com\u00fan de la ada y el a1r de adenosina durante el proceso de desensibilizaci\u00f3n.  este es el primer estudio donde se demuestra que un miembro de la familia de receptores acoplados a prote\u00edna g requiere una ectoenzima, cuyo sustrato es el ligando del receptor, para una eficiente se\u00f1alizaci\u00f3n y regulaci\u00f3n funcional.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interaccion funcional entre la adenosina desaminasa y el receptor a1 de adenosina en la superficie celular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interaccion funcional entre la adenosina desaminasa y el receptor a1 de adenosina en la superficie celular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos A Saura Antolin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Franco Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 enrique Esquerda colell <\/li>\n<li>Alberto Mu\u00f1oz terol (vocal)<\/li>\n<li>joan Serratosa serd? (vocal)<\/li>\n<li>Manuel Ros perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos A Saura Antolin La adenosina deaminasa (ada) es una enzima del metabolismo pur\u00ednico que ha sido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,160,561,3178,17],"tags":[15488,98806,37453,18863,7154,34019],"class_list":["post-37847","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-bioquimica","category-farmacologia-molecular","category-proteinas","category-quimica","tag-alberto-munoz-terol","tag-carlos-a-saura-antolin","tag-joan-serratosa-serd","tag-jose-enrique-esquerda-colell","tag-manuel-ros-perez","tag-rafael-franco-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37847"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37847\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}