{"id":37849,"date":"2018-03-09T09:37:09","date_gmt":"2018-03-09T09:37:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-conocimientos-sobre-la-bilirrubina-bilirrubina-covalente-y-bilirrubina-eritrocitaria\/"},"modified":"2018-03-09T09:37:09","modified_gmt":"2018-03-09T09:37:09","slug":"nuevos-conocimientos-sobre-la-bilirrubina-bilirrubina-covalente-y-bilirrubina-eritrocitaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevos-conocimientos-sobre-la-bilirrubina-bilirrubina-covalente-y-bilirrubina-eritrocitaria\/","title":{"rendered":"Nuevos conocimientos sobre la bilirrubina: bilirrubina covalente y bilirrubina eritrocitaria."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Rosario Amelia Lopez Cueto <\/strong><\/h2>\n<p>La ictericia es un signo cl\u00ednico de gran importancia en las enfermedades hematol\u00f3gicas y, sobre todo, hepatobiliares. Desde 1.916 sabemos que es consecuencia del ascenso de la bilirrubina. Gracias a los estudios de van den berg, conocemos que la bilirrubina en las ictericias prehep\u00e1ticas -hemol\u00edticas-, tiene un comportamiento diferente de las ictericias hep\u00e1ticas (parenquimatosas) y posthep\u00e1ticas (obstructivas). Este comportamiento de la bilirrubina es debido a la conjugaci\u00f3n en el h\u00edgado con el \u00e1cido glucur\u00f3nico y es indispensable para catalogar las hiperbilirrubinemias en dos grandes grupos: hiperbilirrubinemias indirectas hiperbilirrubinemias directas, y por tanto para diferenciar las enfermedades hemol\u00edticas de las hepato-biliares.  bilirrubina covalente: el descubrimiento de una nueva fracci\u00f3n bilirrub\u00ednica -bilirrubina delta-, unida fuertemente a la alb\u00famina, ha supuesto un importante avance en el conocimiento fisiopatol\u00f3gico de los pigmentos biliares, cuyo inter\u00e9s radica en:  i. Interes fisiologico: no se encuentra en la orina, ni en bilis de pacientes con colostasis.  ii. Interes diagnostico: diferencia una ictericia hemol\u00edtica de otra parenquimatosa y\/o colost\u00e1tica, pero carece de valor diagn\u00f3stico diferencial entre estos dos \u00faltimos tipos de hiperbilirrubinemias, siendo s\u00f3lo es un \u00edndice de enfermedad hep\u00e1tica.  iii. Importancia pronostico-evolutiva: la determinaci\u00f3n simult\u00e1nea de la bilirrubina directa y covalente, permite obtener datos de inter\u00e9s pron\u00f3stico.  a) en hepatopat\u00edas parenquimatosas y\/o colost\u00e1ticas de evoluci\u00f3n favorable, se produce disociaci\u00f3n cl\u00ednico-bioquimica (ictericia sin coluria).  b) en ictericias parenquimatosas de evoluci\u00f3n desfavorable (hepatitis fulminante), la bilirrubina delta fu\u00e9 muy baja; el binomio bilirrubina directa alta y bilirrubina delta baja es un signo bioqu\u00edmico de mal pron\u00f3stico.  bilirrubina eritrocitaria: la capacidad de los hemat\u00edes<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos conocimientos sobre la bilirrubina: bilirrubina covalente y bilirrubina eritrocitaria.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos conocimientos sobre la bilirrubina: bilirrubina covalente y bilirrubina eritrocitaria. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Rosario Amelia Lopez Cueto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Rodr\u00edguez Cuartero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Gomez capilla <\/li>\n<li>Manuel Martin gonzalez (vocal)<\/li>\n<li>Francisco Perez blanco (vocal)<\/li>\n<li>Jos\u00e9 Vicente rull (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Rosario Amelia Lopez Cueto La ictericia es un signo cl\u00ednico de gran importancia en las enfermedades [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139],"tags":[4060,9665,3668,60346,98811,74060],"class_list":["post-37849","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","tag-antonio-rodriguez-cuartero","tag-francisco-perez-blanco","tag-jose-antonio-gomez-capilla","tag-jose-vicente-rull","tag-m-rosario-amelia-lopez-cueto","tag-manuel-martin-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37849"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37849\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}