{"id":37850,"date":"2018-03-09T09:37:09","date_gmt":"2018-03-09T09:37:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-microesferas-de-polimeros-biodegradables-al-desarrollo-de-vacunas-de-peptidos-y-protea%c2%adnas\/"},"modified":"2018-03-09T09:37:09","modified_gmt":"2018-03-09T09:37:09","slug":"aplicacion-de-microesferas-de-polimeros-biodegradables-al-desarrollo-de-vacunas-de-peptidos-y-protea%c2%adnas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aplicacion-de-microesferas-de-polimeros-biodegradables-al-desarrollo-de-vacunas-de-peptidos-y-protea%c2%adnas\/","title":{"rendered":"Aplicaci\u00f3n de microesferas de polimeros biodegradables al desarrollo de vacunas de peptidos y prote\u00ednas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuela Igartua Olaechea <\/strong><\/h2>\n<p>Estudios realizados recientemente, han investigado la posible aplicaci\u00f3n de la encapsulaci\u00f3n de ant\u00edgenos de naturaleza prote\u00edca en sistemas microparticulares, al desarrollo de nuevas vacunas para inmunizaci\u00f3n tanto oral como parenteral. entre las ventajas que aportan estas nuevas formas de administraci\u00f3n de vacunas se encuentran la potenciaci\u00f3n de la respuesta inmune, es decir, un efecto inmunoadyuvante la reducci\u00f3n del n\u00famero de inoculaciones necesarias, as\u00ed como una reducci\u00f3n de la dosis total de ant\u00edgeno requerida para lograr una adecuada respuesta. Adem\u00e1s, en el caso de la administraci\u00f3n oral, la encapsulaci\u00f3n protege al ant\u00edgeno de la acidez g\u00e1strica y enzimas proteol\u00edticos. en este trabajo se han optimizado las condiciones de microencapsulaci\u00f3n de una prote\u00edna modelo, la seroalb\u00famina bovina (bsa), con un pol\u00edmero biodegradable, el \u00e1cido polil\u00e1ctico-co-glic\u00f3lico (plga) mediante la t\u00e9cnica de evaporaci\u00f3n\/extracci\u00f3n del solvente, pudi\u00e9ndose controlar el tama\u00f1o de las micropart\u00edculas en un rango comprendido entre 1 y 25 um. Las formulaciones elaboradas presentan un perfil de liberaci\u00f3n bif\u00e1sico, con un efecto burst inicial seguido de una liberaci\u00f3n sostenida. Los estudios de estabilidad de la bsa encapsulada han puesto de manifiesto que las condiciones de microencapsulaci\u00f3n no alteran la integridad de la prote\u00edna y que \u00e9sta se mantiene durante las primeras semanas de su liberaci\u00f3n in vitro. Finalmente, evaluada la respuesta inmune inducida en ratones balb\/c tras la administraci\u00f3n oral o sist\u00e9mica de las microesferas se observ\u00f3 que el proceso de microencapsulaci\u00f3n no s\u00f3lo afecta a la capacidad inmunog\u00e9nica de la prote\u00edna, sino que adem\u00e1s, las microesferas presentan un efecto inmunoadyuvante comparable al del adyuvante completo de freund (acf), con la ventaja de ser biocompatibles y no inducir ning\u00fan tipo de reacci\u00f3n adversa en el lugar de inyecci\u00f3n. Los resultados obtenidos en esta memoria e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaci\u00f3n de microesferas de polimeros biodegradables al desarrollo de vacunas de peptidos y prote\u00ednas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaci\u00f3n de microesferas de polimeros biodegradables al desarrollo de vacunas de peptidos y prote\u00ednas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuela Igartua Olaechea <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Domenech berrozpe <\/li>\n<li>Manuel Guzm\u00e1n navarro (vocal)<\/li>\n<li> Garc\u00eda s\u00e1nchez M\u00aa Jos\u00e9 (vocal)<\/li>\n<li>Mar\u00eda  dolores Torres l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuela Igartua Olaechea Estudios realizados recientemente, han investigado la posible aplicaci\u00f3n de la encapsulaci\u00f3n de ant\u00edgenos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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