{"id":37904,"date":"1998-12-02T00:00:00","date_gmt":"1998-12-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-entre-el-virus-del-sida-y-los-linfocitos-t-alteraciones-funcionales-mediadas-por-ecto-adenosina-desaminasa-y-cd26\/"},"modified":"1998-12-02T00:00:00","modified_gmt":"1998-12-02T00:00:00","slug":"interaccion-entre-el-virus-del-sida-y-los-linfocitos-t-alteraciones-funcionales-mediadas-por-ecto-adenosina-desaminasa-y-cd26","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/interaccion-entre-el-virus-del-sida-y-los-linfocitos-t-alteraciones-funcionales-mediadas-por-ecto-adenosina-desaminasa-y-cd26\/","title":{"rendered":"Interaccion entre el virus del sida y los linfocitos t. alteraciones funcionales mediadas por ecto-adenosina desaminasa y cd26."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Agustin Valenzuela Fernandez <\/strong><\/h2>\n<p>La tesis doctoral versa sobre c\u00f3mo la interacci\u00f3n fisiol\u00f3gica entre la ecto-ada y el cd26 est\u00e1 modulada por el virus vih (virus del sida). Se demuestra que en c\u00e9lulas t y b humanas la uni\u00f3n de ada a cd26 se inhibe por la prote\u00edna viral gp120 tanto en su forma soluble como asociada a la cubierta viral, e independientemente de la expresi\u00f3n del receptor cd4. Esta inhibici\u00f3n de la uni\u00f3n no depende de la actividad dpp iv del cd26 y requiere de una interacci\u00f3n previa de la prote\u00edna gp120 con el cd4 u otros componentes de la superficie celular.  por otro lado, los resultados muestran que los anticuerpos neutralizantes anti-v3 bloquean completamente la uni\u00f3n del virus vih a la superficie de c\u00e9lulas cd4+ y cd4-. Por lo tanto, la capacidad neutralizante de los anticuerpos anti-v3 es consecuencia de la inhibici\u00f3n de la uni\u00f3n gp120\/cd4 y no de la interrupci\u00f3n de la interacci\u00f3n con el correceptor en etapas de postuni\u00f3n con cd4, como hasta ahora se acepta. La integridad de la regi\u00f3n v3 es esencial para la interacci\u00f3n vih-c\u00e9lula hu\u00e9sped. Se ha identificado una prote\u00edna celular, de 95 kda de peso molecular, capaz de unirse a la regi\u00f3n v3, de forma que se encuentra implicada en la entrada e infecci\u00f3n de virus vih-1 t-tr\u00f3picos.  adem\u00e1s, se demuestra que la interacci\u00f3n ada\/cd26 en la superficie de la c\u00e9lula t aumenta la acumulaci\u00f3n de fosfatos de inositol y la movilizaci\u00f3n de calcio intracelular mediada por el anticuerpo monoclonal anti-cd3 okt3. Interesantemente, este efecto sin\u00e9rgico se bloquea en presencia de la prote\u00edna viral gp120 de cepas t-tr\u00f3picas del virus vih, y ocurre tanto en c\u00e9lulas humanas jurkat t cd4+ como en c\u00e9lulas t cd4+ purificadas de sangre perif\u00e9rica de donantes sanos, y de forma independiente del cd4.  debido a que la deficiencia en ada rinde scid, es posible que el bloqueo de la uni\u00f3n ada\/cd26 mediado por el virus vih pueda tener consecuencias significativas en la patog\u00e9nesis del sid<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interaccion entre el virus del sida y los linfocitos t. alteraciones funcionales mediadas por ecto-adenosina desaminasa y cd26.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interaccion entre el virus del sida y los linfocitos t. alteraciones funcionales mediadas por ecto-adenosina desaminasa y cd26. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Agustin Valenzuela Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/02\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Franco Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan Guinovart cirera <\/li>\n<li>Antonio Celada cotarelo (vocal)<\/li>\n<li>Francisco Sanchez Madrid (vocal)<\/li>\n<li>buenaventura Clotet sala (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Agustin Valenzuela Fernandez La tesis doctoral versa sobre c\u00f3mo la interacci\u00f3n fisiol\u00f3gica entre la ecto-ada y el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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