{"id":37933,"date":"2018-03-09T09:37:16","date_gmt":"2018-03-09T09:37:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-de-la-permeacion-transdermica-de-alprazolam\/"},"modified":"2018-03-09T09:37:16","modified_gmt":"2018-03-09T09:37:16","slug":"estudios-de-la-permeacion-transdermica-de-alprazolam","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudios-de-la-permeacion-transdermica-de-alprazolam\/","title":{"rendered":"Estudios de la permeaci\u00f3n transdermica de alprazolam"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Boix Monta\u00f1es <\/strong><\/h2>\n<p>Se han realizado diferentes estudios in vitro de permeaci\u00f3n de alprazolam a trav\u00e9s de piel humana basados en diferentes modelos de difusi\u00f3n transd\u00e9rmica de solutos. El principal objetivo de estos estudios ha sido el de llegar a obtener una aproximaci\u00f3n a un sistema de administraci\u00f3n transd\u00e9rmica de este f\u00e1rmaco.  inicialmente se ha evaluado el perfil de permeaci\u00f3n intr\u00edseca de alprazolam en soluci\u00f3n acuosa a ph 7.4  utilizando un modelo de difusi\u00f3n de una dosis infinita de f\u00e1rmaco. Puede afirmarse que la permeabilidad intr\u00ednseca del alprazolam no es suficiente para resultar terap\u00e9utica.  a partir de estos resultados se ha evaluado la eficacia promotora de diferentes sustancias alif\u00e1ticas (pertenecientes a diferentes grupos qu\u00edmicos) sobre la permeaci\u00f3n basal de alprazolam utilizando un modelo de difusi\u00f3n de una dosis finita de f\u00e1rmaco. La eficacia promotora de estas sustancias se ha cuantificado con el uso de diferentes par\u00e1metros de permeaci\u00f3n.  con el uso de los promotores m\u00e1s eficaces se ha estudiado la permeaci\u00f3n de alprazolam formulado en dos aproximaciones diferentes a un sistema de administraci\u00f3n transd\u00e9rmica: sistema matricial y sistema de reservorio. determinadas formulaciones de f\u00e1rmaco y promotores han permitido obtener valores de velocidad transd\u00e9rmica de permeaci\u00f3n que pueden resultar terap\u00e9uticas en su adminsitraci\u00f3n al organismo humano.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios de la permeaci\u00f3n transdermica de alprazolam<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios de la permeaci\u00f3n transdermica de alprazolam <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Boix Monta\u00f1es <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Concepci\u00f3n Peraire Guitart<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: matias a. Llabres Martinez <\/li>\n<li>rosendo Obach vidal (vocal)<\/li>\n<li>joaqu\u00edn Moreno dalmau (vocal)<\/li>\n<li>Jos\u00e9 bruno Fari\u00f1a espinosa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Boix Monta\u00f1es Se han realizado diferentes estudios in vitro de permeaci\u00f3n de alprazolam a trav\u00e9s de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,9,189,957,3304],"tags":[54416,14228,340,76974,26005,21107],"class_list":["post-37933","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-preparacion-de-farmacos","tag-antonio-boix-montanes","tag-concepcion-peraire-guitart","tag-joaquin-moreno-dalmau","tag-jose-bruno-farina-espinosa","tag-matias-a-llabres-Martinez","tag-rosendo-obach-vidal"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37933"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37933\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}