{"id":37967,"date":"2018-03-09T09:37:19","date_gmt":"2018-03-09T09:37:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deplecion-selectiva-de-los-linfocitos-cd4-mas-ajuste-del-contenido-de-los-cd8-del-injerto-contra-huesped-en-pacientes-de-alto-riesgo-sometidos-a-trasplante-alogenico-de-medula-osea\/"},"modified":"2018-03-09T09:37:19","modified_gmt":"2018-03-09T09:37:19","slug":"deplecion-selectiva-de-los-linfocitos-cd4-mas-ajuste-del-contenido-de-los-cd8-del-injerto-contra-huesped-en-pacientes-de-alto-riesgo-sometidos-a-trasplante-alogenico-de-medula-osea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/deplecion-selectiva-de-los-linfocitos-cd4-mas-ajuste-del-contenido-de-los-cd8-del-injerto-contra-huesped-en-pacientes-de-alto-riesgo-sometidos-a-trasplante-alogenico-de-medula-osea\/","title":{"rendered":"Deplecion selectiva de los linfocitos cd4+ mas ajuste del contenido de los cd8+ del injerto contra huesped en pacientes de alto riesgo sometidos a trasplante alog\u00e9nico de m\u00e9dula \u00f3sea."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada C. Herrera Arroyo <\/strong><\/h2>\n<p>La depleci\u00f3n t de la m\u00e9dula \u00f3sea del donante constituye el m\u00e9todo m\u00e1s eficaz conocido de profilaxis de la enfermedad injerto contra huesped (eih). sin embargo lleva aparejado un incremento en las tasas de rechazo del injerto y de recaida leuc\u00e9mica que hacen que la reducci\u00f3n en la incidencia de eih no se traduzca en una mejora de la supervivencia libre de enfermedad. Presentamos los resultados de un nuevo modelo de depleci\u00f3n t selectiva consistente en la eliminaci\u00f3n de la totalidad de los linfocitos cd4+ y la reducci\u00f3n del contenido de los cd8+ a 1 mill\u00f3n de c\u00e9lulas por kg., De peso en 30 pacientes de alto riesgo de eih. Nuestros resultados indican que el m\u00e9todo utilizado de depleci\u00f3n t reduce la incidencia de eih aguda a un 25% de grados ii, sin que se objetive ning\u00fan grado severo iii \u00f3 iv, con tasas de fracaso del injerto y e reca\u00edda leuc\u00e9mica no incrementadas por el procedimiento.  el an\u00e1lisis de los posibles factores que influyen sobre la incidencia de eih revel\u00f3 que \u00fanicamente la profilaxis adicional con ciclosporina + metrotexate resulta estad\u00edsticamente significativa.  se analiza tambi\u00e9n la incidencia de quimerismo mixto en nuestra serie, que result\u00f3 ser del 34%, la c\u00faal es inferior a la reportada tras depleci\u00f3n pan t.  respecto a la recuperaci\u00f3n inmunol\u00f3gica en nuestros pacientes, fue normal salvo por un marcado retraso en la normalizaci\u00f3n de los niveles de linfocitos cd19+ y cd4+.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Deplecion selectiva de los linfocitos cd4+ mas ajuste del contenido de los cd8+ del injerto contra huesped en pacientes de alto riesgo sometidos a trasplante alog\u00e9nico de m\u00e9dula \u00f3sea.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Deplecion selectiva de los linfocitos cd4+ mas ajuste del contenido de los cd8+ del injerto contra huesped en pacientes de alto riesgo sometidos a trasplante alog\u00e9nico de m\u00e9dula \u00f3sea. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada C. Herrera Arroyo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/03\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Torres G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Jim\u00e9nez perep\u00e9rez <\/li>\n<li>Miguel \u00e1ngel Sanz alonso (vocal)<\/li>\n<li>Luis Madebo l\u00f3pez (vocal)<\/li>\n<li>enrique Aguilar benitez de lugo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada C. Herrera Arroyo La depleci\u00f3n t de la m\u00e9dula \u00f3sea del donante constituye el m\u00e9todo m\u00e1s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,973,218,139],"tags":[29697,2380,99024,1614,99025,9706],"class_list":["post-37967","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cordoba","category-hematologia","category-medicina-interna","tag-antonio-torres-gomez","tag-enrique-aguilar-benitez-de-lugo","tag-inmaculada-c-herrera-arroyo","tag-jose-antonio-jimenez-pereperez","tag-luis-madebo-lopez","tag-miguel-angel-sanz-alonso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=37967"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/37967\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=37967"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=37967"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=37967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}