{"id":38003,"date":"2018-03-09T09:37:22","date_gmt":"2018-03-09T09:37:22","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-proteina-hha-es-un-modulador-global-de-la-expresion-genica-en-escherichia-coli\/"},"modified":"2018-03-09T09:37:22","modified_gmt":"2018-03-09T09:37:22","slug":"la-proteina-hha-es-un-modulador-global-de-la-expresion-genica-en-escherichia-coli","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-proteina-hha-es-un-modulador-global-de-la-expresion-genica-en-escherichia-coli\/","title":{"rendered":"La proteina hha es un modulador global de la expresion genica en escherichia coli."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Balsalobre Parra <\/strong><\/h2>\n<p>La prote\u00edna hha es un modulador descrito inicialmente como un factor regulador de la expresi\u00f3n de factores de virulencia. Se ha demostrado que las cepas mutantes hha presentan caracter\u00edsticas que han permitido relacionar a la prote\u00edna hha con el grupo de prote\u00ednas asociadas al nucleoide. As\u00ed, la mutaci\u00f3n hha a la topolog\u00eda del adn, tiene un claro fenotipo pleiotr\u00f3pico y la capacidad moduladora de la prote\u00edna hha es dependiente de un par\u00e1metro ambiental como es osmolaridad del medio de cultivo. Adem\u00e1s la sobreexpresi\u00f3n del gen hha provoca un incremento en la frecuencia de movilizaci\u00f3n de secuencias de inserci\u00f3n. La prote\u00edna hha sufre modificaciones postraduccionales, como se evidencia al detectar la existencia de tres isoformas de la prote\u00edna en el interior de la c\u00e9lula.  se ha podido demostrar que la osmolaridad del medio de cultivo es un factor determinante en la modificaci\u00f3n postraduccional de la prote\u00edna y, por tanto, en la determinaci\u00f3n de su bioactividad. Las modificaciones postraduccionales detectadas son el procesamiento de la metionina aminoterminal y la fosforilaci\u00f3n de la fosforilaci\u00f3n de la prote\u00edna. La fosforilacion es un paso determinante de la bioactividad de la prote\u00edna que, como se ha podido demostrar, es la uni\u00f3n al adn.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La proteina hha es un modulador global de la expresion genica en escherichia coli.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La proteina hha es un modulador global de la expresion genica en escherichia coli. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Balsalobre Parra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/03\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Mu\u00f1oa Mardomingo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Ju\u00e1rez gim\u00e9nez <\/li>\n<li>josep Casadesus pursals (vocal)<\/li>\n<li>daniel Grinberg vaisman (vocal)<\/li>\n<li>Juan  Carlos Alonso navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Balsalobre Parra La prote\u00edna hha es un modulador descrito inicialmente como un factor regulador de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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