{"id":38019,"date":"2018-03-09T09:37:23","date_gmt":"2018-03-09T09:37:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/carcterizacion-del-eje-hipotalamo-pituitatrio-adrenal-hpa-en-cepas-consangua%c2%adneas-de-rata-posible-relacion-con-un-modelo-animal-de-depresion\/"},"modified":"2018-03-09T09:37:23","modified_gmt":"2018-03-09T09:37:23","slug":"carcterizacion-del-eje-hipotalamo-pituitatrio-adrenal-hpa-en-cepas-consangua%c2%adneas-de-rata-posible-relacion-con-un-modelo-animal-de-depresion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/carcterizacion-del-eje-hipotalamo-pituitatrio-adrenal-hpa-en-cepas-consangua%c2%adneas-de-rata-posible-relacion-con-un-modelo-animal-de-depresion\/","title":{"rendered":"Carcterizaci\u00f3n del eje hipot\u00e1lamo-pituitatrio-adrenal (hpa) en cepas consangu\u00edneas de rata: posible relaci\u00f3n con un modelo animal de depresi\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisca G\u00f3mez Oliver <\/strong><\/h2>\n<p>Considerando la relaci\u00f3n que existe entre estr\u00e9s, depresi\u00f3n y el eje hpa y que algunos tipos de depresi\u00f3n tienen base gen\u00e9tica, estudiamos la actividad basal del eje hpa y la respuesta al estr\u00e9s, en las cepas consagu\u00edneas de rata bn, fis, lew, shr y wky. La conducta de estas cepas, caracterizada en el test de nataci\u00f3n forzada, considerado como un modelo animal de depresi\u00f3n, indicada que las cepas bn y wky pod\u00edan ser consideradas como posibles modelos animales de depresi\u00f3n. Por otro lado, y formando parte del segundo bloque del trabajo, estudiamos tambi\u00e9n la cepa fh, caracterizada por alteraciones en la funci\u00f3n serotonin\u00e9rgica tanto central como perif\u00e9rica (por lo que podr\u00eda ser considerada como un posible modelo animal de depresi\u00f3n) as\u00ed como por una hiperactividad basal del eje hpa, que podr\u00eda ser normalizada tras la administraci\u00f3n de antidepresivos, utilizando como cepa control la cepa no consangu\u00ednea sd. Los resultados del primer bloque de estudio indicaron:  1,- que no hay diferencias entre cepas en los niveles basales de actividad del eje pa, ni en los niveles del mrna y del crf en el pvn del hipot\u00e1lamo, ni en el de los mr y gr en hipocampo.  2,- la respuesta de las cepas al estr\u00e9s agudo dependen de las caracter\u00edsticas del est\u00edmulo estresante utilizado.  3,- el estr\u00e9s cr\u00f3nico indujo cambios similares a nivel hipocampal, hipotal\u00e1mico y hipofisario, observ\u00e1ndose los efectos diferenciales sobre la actividad basal del eje a nivel de hipercoricosteronemia basal y de hipertrofia adrenal, indicando que las diferencias entre las cepas se localizarian b\u00e1sicamente a nivel adrenal.  4,- solamente la cepa bn mostr\u00f3 cierta resistencia a la supresi\u00f3n del eje pa, que fue aparentemente independiente de factores farmacocin\u00e9ticos y de alteraciones en los receptores de corticosteroides en hipocambo o hipot\u00e1lamo.  5,- en ausencia de feedback negativo la cepa lew y shr no incrementaron la acth en respuesta al estr\u00e9<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Carcterizaci\u00f3n del eje hipot\u00e1lamo-pituitatrio-adrenal (hpa) en cepas consangu\u00edneas de rata: posible relaci\u00f3n con un modelo animal de depresi\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Carcterizaci\u00f3n del eje hipot\u00e1lamo-pituitatrio-adrenal (hpa) en cepas consangu\u00edneas de rata: posible relaci\u00f3n con un modelo animal de depresi\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisca G\u00f3mez Oliver <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Armario Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: albert Badia sancho <\/li>\n<li>joan De pablo rabass\u00f3 (vocal)<\/li>\n<li>carmen Guaza rodriguez (vocal)<\/li>\n<li>olga Pol rigau (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisca G\u00f3mez Oliver Considerando la relaci\u00f3n que existe entre estr\u00e9s, depresi\u00f3n y el eje hpa y que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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