{"id":38036,"date":"1998-02-04T00:00:00","date_gmt":"1998-02-04T00:00:00","guid":{"rendered":""},"modified":"1998-02-04T00:00:00","modified_gmt":"1998-02-04T00:00:00","slug":"mutaciones-del-gen-de-la-apoproteina-e-determinada-por-la-enzima-de-restriccion-cfo-1-y-c-iii-determinada-por-la-enzima-sst-i-y-su-efecto-sobre-los-factores-de-riesgo-cardiovascular-en-transplant","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mutaciones-del-gen-de-la-apoproteina-e-determinada-por-la-enzima-de-restriccion-cfo-1-y-c-iii-determinada-por-la-enzima-sst-i-y-su-efecto-sobre-los-factores-de-riesgo-cardiovascular-en-transplant\/","title":{"rendered":"Mutaciones del gen de la apoproteina e (determinada por la enzima de restricci\u00f3n (cfo-1) y c-iii (determinada por la enzima sst-i) y su efecto sobre los factores de riesgo cardiovascular en transplantados de coraz\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angel Gonz\u00e1lez Amieva <\/strong><\/h2>\n<p>Introduccion  la aterosclerosis acelerada del injerto es la principal causa de morbimortalidad a largo plazo en enfermos trasplantados de coraz\u00f3n, y su patogenia, forma de presentacion y etiolog\u00eda (en la que cobra gran relevancia la presencia de hiperlipemia postrasplante), difieren de la encontrada en la poblaci\u00f3n general. Por otra parte, los polimorfismos de los genes de la apoprote\u00edna c-iii, regi\u00f3n promotora de la apo a-i, y sobre todo de la apo e (en su variante e3e4), se han asociado al desarrollo de arteriosclerosis coronaria en la poblaci\u00f3n general, principalmente por un empeoramiento del perfil lip\u00eddico.  objetivos  conocer la relaci\u00f3n entre las variaciones gen\u00e9ticas de las apoprote\u00ednas citadas y el desarrollo de arteriosclerosis postrasplante en trasplantados de coraz\u00f3n. Intentar asociar estas variantes con la presencia de hiperlipemia postrasplante y otros factores de riesgo cardiovascular.  pacientes, material y m\u00e9todos  estudiamos 103 sujetos sometidos a trasplante card\u00edaco y con una supervivencia mayor de un a\u00f1o. Determinamos el diagn\u00f3stico de arteriosclerosis por arteriograf\u00eda. recogemos un protocolo de anal\u00edtica b\u00e1sica, perfil lip\u00eddico y factores de riesgo cardiovascular, y finalmente determinamos a cada uno las variantes gen\u00e9ticas de las tres apoprote\u00ednas citadas.  resultados  la presencia del genotipo gg de la regi\u00f3n promotora de la apo a-i y de las variantes e3e4 y e3e2 de la apo e, determinaban cada una de forma independiente de otros par\u00e1metros un 4,5% de la variabilidad de esta complicaci\u00f3n, probablemente sin relacionarse con alteraciones en el perfil lip\u00eddico. los genotipos e3e2 y ga se asociaba con m\u00e1s frecuencia a hipertrigliceridemia tras el trasplante card\u00edaco, mientras el ga provocaba tambi\u00e9n mayores cifras de colesterol-ldl. Tras el trasplante card\u00edaco se produc\u00eda un aumento en la preValencia de diabetes mellitus, hipertensi\u00f3n arterial e hiperlipemia.  conclusiones  la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mutaciones del gen de la apoproteina e (determinada por la enzima de restricci\u00f3n (cfo-1) y c-iii (determinada por la enzima sst-i) y su efecto sobre los factores de riesgo cardiovascular en transplantados de coraz\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mutaciones del gen de la apoproteina e (determinada por la enzima de restricci\u00f3n (cfo-1) y c-iii (determinada por la enzima sst-i) y su efecto sobre los factores de riesgo cardiovascular en transplantados de coraz\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angel Gonz\u00e1lez Amieva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/04\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Perez Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Jim\u00e9nez perep\u00e9rez <\/li>\n<li>Manuel Concha ruiz (vocal)<\/li>\n<li>pedro Benito lopez (vocal)<\/li>\n<li>Luis Hidalgo rojas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angel Gonz\u00e1lez Amieva Introduccion la aterosclerosis acelerada del injerto es la principal causa de morbimortalidad a largo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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