{"id":38052,"date":"2018-03-09T09:37:26","date_gmt":"2018-03-09T09:37:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-de-permeacion-transdermica-y-actividad-topica-de-una-serie-de-antiinflamatorios-no-esteroides\/"},"modified":"2018-03-09T09:37:26","modified_gmt":"2018-03-09T09:37:26","slug":"estudios-de-permeacion-transdermica-y-actividad-topica-de-una-serie-de-antiinflamatorios-no-esteroides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudios-de-permeacion-transdermica-y-actividad-topica-de-una-serie-de-antiinflamatorios-no-esteroides\/","title":{"rendered":"Estudios de permeaci\u00f3n transdermica y actividad topica de una serie de antiinflamatorios no esteroides"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Antonio Cordero Rigol <\/strong><\/h2>\n<p>Se realiza un estudio comparativo in vitro del paso a trav\u00e9s de piel humana de una serie de aines (indometacina, ketoprofeno, diclofenaco, piroxicam, tenoxicam, ketorolaco y aceclofenaco) paa conocer los principales par\u00e1metros de permeaci\u00f3n: constante de permeabilidad, flujo y per\u00edodo de latencia. los mayores valores de flujo correspondieron a ketoprofeno y ketorolaco (16 y 13 ug-h-1 cm2, respectivamente). Se determino adem\u00e1s la solubilidad y el coeficiente de reparto experimental e intr\u00edseco, y se encontr\u00f3 una correlaci\u00f3n significativa entre lipofilia intrinseca y constante de permeabilidad (r2 = 0,745, p=0,01, n=7), confirmando que la lipofilia es un factor que influye en la permeaci\u00f3n de aines a trav\u00e9s de la piel. Se predicen las concentraciones en estado de equilibrio estacionario que se obtendr\u00edan in vivo suponiendo un parte transd\u00e9rmico de 16 cm2, obteniendose valores de 123 a 967 veces inferiores a las concentraciones terap\u00e9uticas, a excepci\u00f3n del ketorolaco que estar\u00eda alejado solamente en unas 25 veces. Ketorolaco es, por tanto, un buen candidao para ser formulado por sat en presencia de promotores de la permeaci\u00f3n. Por otro lado, se estudia la actividad antiinflamatoria de los siete aines es un modelo farmacol\u00f3gico in vitro que consiste en cultivos celulares de fibroblastos humanos previamente inducidos para aumentar la producci\u00f3n del enzima cox-2, simulando as\u00ed las condiciones que se dar\u00edan en c\u00e9lulas inflamadas de la piel. En este modelo, diclofenaco fue el f\u00e1rmaco de la serie con mayor actividad inhibidora de la cox-2 (ic50=0,03 um) segudio de indometacina y ketorolaco (ic50=0,16 y 0,38 um, respectivamente). Finalmente, se propone un \u00edndice de actividad antiinflamatoria t\u00f3pica (iaat) estimado conociendo el flujo de paso a trav\u00e9s de piel humana obtenido in vitro y un indicador de la potencia antiinflamatoria (ic50). En este sentido, diclofenaco (iaat=9,7) y ketrolaco (iaat=8,1) ser\u00edan los f\u00e1rmacos de l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios de permeaci\u00f3n transdermica y actividad topica de una serie de antiinflamatorios no esteroides<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios de permeaci\u00f3n transdermica y actividad topica de una serie de antiinflamatorios no esteroides <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Antonio Cordero Rigol <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/04\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Domenech Berrozpe<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 m Pla delfina <\/li>\n<li>Luis Vila navarro (vocal)<\/li>\n<li>josep Queralt regue (vocal)<\/li>\n<li>jordi De bol\u00f3s capdevila (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Antonio Cordero Rigol Se realiza un estudio comparativo in vitro del paso a trav\u00e9s de piel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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