{"id":38120,"date":"1998-05-05T00:00:00","date_gmt":"1998-05-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-de-les-alteracions-en-microsatel-lits-dels-cromosomes-2p-i-3p-en-tumors-no-microcitics-de-pulmo-possibles-implicacions-pronotiques\/"},"modified":"1998-05-05T00:00:00","modified_gmt":"1998-05-05T00:00:00","slug":"estudi-de-les-alteracions-en-microsatel-lits-dels-cromosomes-2p-i-3p-en-tumors-no-microcitics-de-pulmo-possibles-implicacions-pronotiques","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudi-de-les-alteracions-en-microsatel-lits-dels-cromosomes-2p-i-3p-en-tumors-no-microcitics-de-pulmo-possibles-implicacions-pronotiques\/","title":{"rendered":"Estudi de les alteracions en microsatel. lits dels cromosomes 2p i 3p en tumors no microcitics de pulmo: possibles implicacions pronotiques."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alex Pifarre Rubbel <\/strong><\/h2>\n<p>En este estudio se han analizado las alteraciones acontecidas en secuencias microsat\u00e9lite mapadas en los cromosomas 2p y 3p en una serie de 64 pacientes con c\u00e1ncer de pulm\u00f3n no microc\u00edtico pertenecientes a los estadios quir\u00fargicos i, ii y iiia. Las secuencias analizadas corresponden a repeticiones del tipo (ca)n y dicho examen se ha realizado mediante reacci\u00f3n en cadena de la polimerasa con el fin de detectar tanto errores de replicaci\u00f3n como p\u00e9rdidas de heterocigosidad en muestras tumorales y normales de los 64 pacientes.  se ha analizado tambi\u00e9n en dichas muestras la existencia de mutaciones en los genes k-ras y tp53. Todas estas valoraciones a nivel molecular han sido comparadas con las caracter\u00edsticas cl\u00ednicas y patol\u00f3gicas de los pacientes, as\u00ed como su relaci\u00f3n con el pron\u00f3stico de \u00e9stos. Un 66% de los pacientes mostr\u00f3 errores de replicaci\u00f3n en alguno de los microsat\u00e9lites analizados, mientras que un 36% mostr\u00f3 p\u00e9rdidas de heterocigosidad.  los pacientes en estadio i con er presentaron una supervivencia del 26% frente al 80% de aquellos que no mostraron er (p=0.005). De estos pacientes, aqu\u00e9llos que ten\u00edan un tama\u00f1o tumoral superior a 3 cm (t2) no sobreviv\u00edan al cabo de 36 meses (p=0.001). Este estudio muestra que los er son frecuentes y constituyen un factor pron\u00f3stico importante en cp en estadio i.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi de les alteracions en microsatel. lits dels cromosomes 2p i 3p en tumors no microcitics de pulmo: possibles implicacions pronotiques.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi de les alteracions en microsatel. lits dels cromosomes 2p i 3p en tumors no microcitics de pulmo: possibles implicacions pronotiques. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alex Pifarre Rubbel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/05\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Rosell Costa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Merce Durfort Coll <\/li>\n<li>Aurelio Ariza Fern\u00e1ndez (vocal)<\/li>\n<li>Josep Mar\u00eda De Anta Vinyals (vocal)<\/li>\n<li>Agust\u00ed Barnadas Molins (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alex Pifarre Rubbel En este estudio se han analizado las alteraciones acontecidas en secuencias microsat\u00e9lite mapadas en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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