{"id":38148,"date":"2018-03-09T09:37:35","date_gmt":"2018-03-09T09:37:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-inmunohistoquimica-de-la-proteina-p53-en-el-cancer-de-mama-asociacion-con-factores-pronosticos\/"},"modified":"2018-03-09T09:37:35","modified_gmt":"2018-03-09T09:37:35","slug":"expresion-inmunohistoquimica-de-la-proteina-p53-en-el-cancer-de-mama-asociacion-con-factores-pronosticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-inmunohistoquimica-de-la-proteina-p53-en-el-cancer-de-mama-asociacion-con-factores-pronosticos\/","title":{"rendered":"Expresion inmunohistoquimica de la proteina p53 en el cancer de mama. asociacion con factores pronosticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Perez Requena <\/strong><\/h2>\n<p>La elevada morbi-mortalidad asociada al c\u00e1ncer de mama y la heterogeneidad en cuanto a su comportamiento han hecho que se realice un gran esfuerzo en la b\u00fasqueda de factores pron\u00f3sticos que determinen subgrupos de pacientes susceptibles de recibir un tratamiento diferente. El gen p53 es un gen supresor tumoral que cuando presenta alteraciones es detectable por t\u00e9cnicas inmunohistoqu\u00edmicas a trav\u00e9s de la prote\u00edna p53. La expresi\u00f3n inmunohistoqu\u00edmica de p53 en el c\u00e1ncer de mama se asocia a una evoluci\u00f3n desfavorable y un mal pron\u00f3stico seg\u00fan algunos estudios, pero seg\u00fan otros esta asociaci\u00f3n es dependiente de otros factores pron\u00f3sticos, no es estad\u00edsticamente significativa o no existe.  el objetivo de esta tesis doctoral es determinar la posible influencia pron\u00f3stica de la expresi\u00f3n inmunohistoqu\u00edmica de la prote\u00edna p53 en el c\u00e1ncer de mama, as\u00ed como determinar si se trata de un factor pron\u00f3stico independiente o est\u00e1 relacionado con otros factores pron\u00f3sticos ya conocidos. Para ello, se han estudiado cien casos de c\u00e1ncer de mama, realizando un estudio descriptivo de par\u00e1metros cl\u00ednico-patol\u00f3gicos y de los factores pron\u00f3sticos cl\u00e1sicos, un estudio de cohorte transversal para comparar el estado de p53 con el resto de los par\u00e1metros y un estudio de cohorte retrospectivo de supervivencia libre de enfermedad y global.  nuestros resultados apoyan que la expresi\u00f3n inmunohistoqu\u00edmica de la prote\u00edna p53 es un factor de mal pron\u00f3stico independiente en el c\u00e1ncer de mama, presentando una menor supervivencia libre de enfermedad y global los casos positivos para p53. El n\u00famero de ganglios linf\u00e1ticos axilares con met\u00e1stasis, la presencia de invasi\u00f3n vascular y el \u00edndice de celularidad tambi\u00e9n se comportan como factores pron\u00f3sticos independientes en nuestro estudio. El tama\u00f1o tumoral grande, la presencia de met\u00e1stasis ganglionares completas o con invasi\u00f3n extracapsular y la negatividad de los recept<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion inmunohistoquimica de la proteina p53 en el cancer de mama. asociacion con factores pronosticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion inmunohistoquimica de la proteina p53 en el cancer de mama. asociacion con factores pronosticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Perez Requena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/05\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M. Jes\u00fas Palomo Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Vaamonde lemos <\/li>\n<li>Antonio Lopez  mu\u00f1oz (vocal)<\/li>\n<li>Jos\u00e9 Aneiros cachaza (vocal)<\/li>\n<li>Manuel Jos\u00e9 Gayoso rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Perez Requena La elevada morbi-mortalidad asociada al c\u00e1ncer de mama y la heterogeneidad en cuanto a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1506,9,52,156],"tags":[1713,35731,99341,99342,9985,20713],"class_list":["post-38148","post","type-post","status-publish","format-standard","hentry","category-cadiz","category-ciencias-medicas","category-histopatologia","category-patologia","tag-antonio-lopez-munoz","tag-jose-aneiros-cachaza","tag-jose-perez-requena","tag-m-jesus-palomo-gonzalez","tag-manuel-jose-gayoso-rodriguez","tag-ricardo-vaamonde-lemos"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=38148"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38148\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=38148"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=38148"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=38148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}